19.1 Inflammatory Dermatoses

Question 1

What is the stem cell layer of the skin?

Answer 1

Stratum Basale

Question 2

What connects the cells of the stratum spinosum?

Answer 2

Desmosomes

Question 3

Are there blood vessels in the epidermis?

Answer 3

NO

Question 4

What is found in the dermis?

Answer 4

• Hair shaft
• Blood vessels
• Sebaceous glands
• Sweat glands

Question 5

What separates the dermis and the epidermis?

Answer 5

Basement Membrane

Question 6

Atopic Dermatitis (Eczema)

Answer 6

Pruritic, erythematous oozing vesicle and edema that often involves the face

Question 7

What is atopic dermatitis associated with?

Answer 7

Asthma and allergic dermatitis

Question 8

Contact Dermatitis

Answer 8

Pruritic, erythematous oozing vesicle and edema that arises from exposure to an antigen

Question 9

What are some common causes of contact dermatitis?

Answer 9

Poison Ivy and Nickel

Question 10

What is the reaction type in atopic dermatitis?

Answer 10

Type I

Question 11

What is the reaction type in contact dermatitis?

Answer 11

Type IV

Question 12

Acne

Answer 12

Chronic inflammation of hair follicles and sebaceous glands - excess keratin blocks the hair follicles

Question 13

What is the infection seen in acne?

Answer 13

Propionibacterium acnes

Question 14

What is the treatment for acne vulgaris?

Answer 14

• Benzoyl peroxide

- Vitamin A derivatives (decreases keratin production)

Question 15

Psoriasis

Answer 15

Well circumscribed salmon colored plaques with a silvery scale often on extensor surfaces and can cause pitting of nails.

Question 16

What is the cause of psoriasis?

Answer 16

Excessive keratinocyte proliferation

Question 17

What gene is psoriasis associated with?

Answer 17

HLA-C

Question 18

What are the histological findings with psoriasis?

Answer 18

• Acanthosis
• Parakeratosis
• Neutrophils in the stratum corneum
• Elongation of the dermal papillae

Question 19

Auspitz’s Sign

Answer 19

Peeling off of the scale leads to a pinpoint bleed

Question 20

What is the treatment for psoriasis?

Answer 20

• Corticosteroids

- Immune-modulation

Question 21

How is UV light used to treat psoriasis?

Answer 21

UVA light is used with the drug psoralen which reduces the proliferation of the cells

Question 22

Lichen Planus

Answer 22

Associated with the P’s - pruritic, planar, polygonal and purple papules

Question 23

What often presents with reticular white lines on the surface - Wickham striae?

Answer 23

Lichen Planus

Question 24

Where does lichen planus affect?

Answer 24

Wrists, elbows and oral mucosa

Question 25

What is seen on histology of lichen planus?

Answer 25

Inflammation at the dermal-epidermal junction

Question 26

What has a saw tooth appearance at the DEJ?

Answer 26

Lichen Planus

Question 27

What infection is lichen planus associated with?

Answer 27

HCV