19.1 Inflammatory Dermatoses Flashcards
What is the stem cell layer of the skin?
Stratum Basale
What connects the cells of the stratum spinosum?
Desmosomes
Are there blood vessels in the epidermis?
NO
What is found in the dermis?
- Hair shaft
- Blood vessels
- Sebaceous glands
- Sweat glands
What separates the dermis and the epidermis?
Basement Membrane
Atopic Dermatitis (Eczema)
Pruritic, erythematous oozing vesicle and edema that often involves the face
What is atopic dermatitis associated with?
Asthma and allergic dermatitis
Contact Dermatitis
Pruritic, erythematous oozing vesicle and edema that arises from exposure to an antigen
What are some common causes of contact dermatitis?
Poison Ivy and Nickel
What is the reaction type in atopic dermatitis?
Type I
What is the reaction type in contact dermatitis?
Type IV
Acne
Chronic inflammation of hair follicles and sebaceous glands - excess keratin blocks the hair follicles
What is the infection seen in acne?
Propionibacterium acnes
What is the treatment for acne vulgaris?
- Benzoyl peroxide
- Vitamin A derivatives (decreases keratin production)
Psoriasis
Well circumscribed salmon colored plaques with a silvery scale often on extensor surfaces and can cause pitting of nails.
What is the cause of psoriasis?
Excessive keratinocyte proliferation
What gene is psoriasis associated with?
HLA-C
What are the histological findings with psoriasis?
- Acanthosis
- Parakeratosis
- Neutrophils in the stratum corneum
- Elongation of the dermal papillae
Auspitz’s Sign
Peeling off of the scale leads to a pinpoint bleed
What is the treatment for psoriasis?
- Corticosteroids
- Immune-modulation
How is UV light used to treat psoriasis?
UVA light is used with the drug psoralen which reduces the proliferation of the cells
Lichen Planus
Associated with the P’s - pruritic, planar, polygonal and purple papules
What often presents with reticular white lines on the surface - Wickham striae?
Lichen Planus
Where does lichen planus affect?
Wrists, elbows and oral mucosa
What is seen on histology of lichen planus?
Inflammation at the dermal-epidermal junction
What has a saw tooth appearance at the DEJ?
Lichen Planus
What infection is lichen planus associated with?
HCV
