13.3 Cervix

Question 1

What cells line the exocervix?

Answer 1

Stratified Squamous

Question 2

What cells line the endocervix?

Answer 2

Simple Columnar

Question 3

What is the demarcation between the ectocervix and endocervix?

Answer 3

Transformation Zone

Question 4

How is HPV transmitted?

Answer 4

Sexual Contact

Question 5

What does persistent HPV infection increase the risk of?

Answer 5

Cervical Intraepithelial Neoplasia

Question 6

What does E6 from HPV bind to?

Answer 6

p53

Question 7

What does E7 from HPV bind to?

Answer 7

Rb

Question 8

What cells are characteristic of CIN?

Answer 8

Koilocytes

Question 9

What is the difference in CIN I, II, III VS carcinoma in-situ?

Answer 9

CIN is reversible but carcinoma is NOT

Question 10

What is the key presentation of cervical carcinoma?

Answer 10

Vaginal Bleeding

Question 11

What are the main risk factors for cervical cancer?

Answer 11

• HPV infection

- Smoking

Question 12

What is the more common type of cervical carcinoma?

Answer 12

Squamous Cell Carcinoma

Question 13

What is a complication of cervical cancer?

Answer 13

Invasion into the bladder which can lead to hydronephrosis and renal obstruction

Question 14

What is the confirmatory test for a Pap smear?

Answer 14

Colposcopy with biopsy

Question 15

What are the limitations of Pap smear?

Answer 15

• Needs to sample transformation zone

- Limited efficacy for adenocarcinoma screening

Question 16

What does the quadrivalent HPV vaccine protect for?

Answer 16

HPV-6, 11, 16 and 18