12.4 Nephritic Syndrome Flashcards
What are the hallmarks of nephritic syndrome?
Glomerular inflammation and bleeding (hematuria)
What are other signs of nephritic syndrome?
- Periorbital edema
- HTN
- RBC casts
What are the lab findings of nephritic syndrome?
Immune complex deposition and neutrophils
What is the pathogenesis of poststreptococcal glomerulonephritis?
After infection with Group A Strep that has M protein it will occur 2-3 weeks after
What is the common patient population for PSGN?
Children
What is seen in microscopy for PSGN?
Subepithelial hump
What is the treatment for PSGN?
Supportive treatment
What is rapidly progressive glomerulonephritis?
Nephritic syndrome that rapidly develops into renal failure
What is characteristic of biopsy from RPGN?
Crescents - made of fibrin and macrophages
What is characteristic in the IF of RPGN?
It indicates RPGN I - Goodpasture Syndrome
What is the classical patient of Goodpasture syndrome?
Young male
What are the most common nephritic syndromes with a granular IF?
PSGN
Diffuse Proliferative GN
What is found in diffuse proliferative GN?
Sub endothelial antibody-Ag deposition
What is the most common type of renal disease in SLE?
Diffuse Proliferative GN
What is the nephrotic syndrome that is associated with SLE?
Membranous Nephropathy
pANCA - where do they bind?
Perinuclear binding
cANCA - where do they bind?
Cytoplasmic binding
What disease is cANCA involved with?
Wegener Granulomatosis
What disease is pANCA involved with?
Charg-Strauss Syndrome
Microscopic Polyangiitis
If a patient presents with hematuria, hemoptysis and sinusitis, what is the most likely diagnosis?
Wegener’s Granulomatosis
What are the differences in Charg-Strauss and microscopic polyangiitis?
Charg-Stauss - granuloma, asthma and eosinophilia
What is the cause if IgA nephropathy?
IgA immune complex deposits in the mesangium
What is IgA nephropathy typically associated with?
Mucosal infections
What is Alport Syndrome?
Inherited defect in type IV collagen that is X–linked and results in the thinning and splitting of the glomerular basement membrane.
