6.6 Lymphoma Flashcards
Lymphoma
Neoplastic proliferation of lymphoid tissue that forms a mass
What are the 2 classes of lymphoma?
- Non-Hodgkin’s Lymphoma
- Hodgkin’s Lymphoma
What is the dark area that surrounds the follicle?
Mantle
What is the area outside of the mantle of the follicle that is sometimes present?
Margin
Follicular Lymphoma
Neoplastic proliferation of small B cells that are CD20+ in the follicle
What is the typical age for follicular lymphoma presentation?
Late adulthood - presents as painless lymphadenopathy
Translocation of Follicular Lymphoma
t(14;18) - IgH BCL2 - causes an overexpression of BCL2
What is the function of BCL2?
Prevention of apoptosis
What is the treatment of follicular lymphoma?
Low dose chemotherapy
Rituximab - CD20 inhibitor
What are the complications of follicular lymphoma?
Development into diffuse large B-cell lymphoma
How can follicular lymphoma be distinguised from hyperplasia?
In hyperplasia: Follicles will remain in the cortical region - macrophages will be present to eat up the debris of apoptotic cells
Lymphoma: Follicles will have BCL2 expression and monoclonality, both of which is abnormal
Mantle Cell Lymphoma
Neoplastic proliferation of small B cells that are CD20+ in the mantle zone
What is the typical age for mantle cell lymphoma presentation?
Late adulthood with painless LAD
Translocation of Mantle Cell Lymphoma
t(11;14) Cyclin D1 - IgH
What is the function of cyclin D1?
Promotes the the G1/S transition of the cell cycle
Marginal Cell Lymphoma
Neoplastic proliferation of small B cells that are CD20+ in the marginal zone
What is marginal cell lymphoma associated with?
Chronic inflammation
- Hashimoto’s Thyroiditis
- Sjogren Syndrome
- H. pylori gastritis
MALToma
Marginal zone lymphoma in mucosal sites
MALT - mucosa-associated lymphoid tissue
Burkitt Lymphoma
Neoplastic intermediate sized B cells that are CD20+
What is Burkitt Lymphoma associated with?
EBV
What does the African form of Burkitt Lymphoma involve?
Jaw
What does the sporadic form of Burkitt Lymphoma arise?
Abdomen
Translocation of Burkitt Lymphoma
t(8;14) cMyc-IgH
What is the function of cMyc?
Promotes cell growth
What is the appearance of Burkitt lymphoma on histology?
“Starry sky” appearance due to the high mitotic rate - large blue area with white spots due to macrophage infiltration
Diffuse Large B-cell Lymphoma
Neoplastic large sized B cells that are CD20+ and grow diffusely in sheets - aggressive
What is the most common non-Hodgkin lymphoma?
Diffuse large B-cell lymphoma
How can DLBCL arise?
Sporadically or as a transformation follicular lymphoma
What does DLBCL present as and at what age?
Late adulthood as an enlarging LN or an extra nodal mass
