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Pathoma > 6.6 Lymphoma > Flashcards

6.6 Lymphoma Flashcards

1
Q

Lymphoma

A

Neoplastic proliferation of lymphoid tissue that forms a mass

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2
Q

What are the 2 classes of lymphoma?

A
  • Non-Hodgkin’s Lymphoma

- Hodgkin’s Lymphoma

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3
Q

What is the dark area that surrounds the follicle?

A

Mantle

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4
Q

What is the area outside of the mantle of the follicle that is sometimes present?

A

Margin

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5
Q

Follicular Lymphoma

A

Neoplastic proliferation of small B cells that are CD20+ in the follicle

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6
Q

What is the typical age for follicular lymphoma presentation?

A

Late adulthood - presents as painless lymphadenopathy

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7
Q

Translocation of Follicular Lymphoma

A

t(14;18) - IgH BCL2 - causes an overexpression of BCL2

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8
Q

What is the function of BCL2?

A

Prevention of apoptosis

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9
Q

What is the treatment of follicular lymphoma?

A

Low dose chemotherapy

Rituximab - CD20 inhibitor

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10
Q

What are the complications of follicular lymphoma?

A

Development into diffuse large B-cell lymphoma

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11
Q

How can follicular lymphoma be distinguised from hyperplasia?

A

In hyperplasia: Follicles will remain in the cortical region - macrophages will be present to eat up the debris of apoptotic cells

Lymphoma: Follicles will have BCL2 expression and monoclonality, both of which is abnormal

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12
Q

Mantle Cell Lymphoma

A

Neoplastic proliferation of small B cells that are CD20+ in the mantle zone

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13
Q

What is the typical age for mantle cell lymphoma presentation?

A

Late adulthood with painless LAD

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14
Q

Translocation of Mantle Cell Lymphoma

A

t(11;14) Cyclin D1 - IgH

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15
Q

What is the function of cyclin D1?

A

Promotes the the G1/S transition of the cell cycle

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16
Q

Marginal Cell Lymphoma

A

Neoplastic proliferation of small B cells that are CD20+ in the marginal zone

17
Q

What is marginal cell lymphoma associated with?

A

Chronic inflammation

  • Hashimoto’s Thyroiditis
  • Sjogren Syndrome
  • H. pylori gastritis
18
Q

MALToma

A

Marginal zone lymphoma in mucosal sites

MALT - mucosa-associated lymphoid tissue

19
Q

Burkitt Lymphoma

A

Neoplastic intermediate sized B cells that are CD20+

20
Q

What is Burkitt Lymphoma associated with?

A

EBV

21
Q

What does the African form of Burkitt Lymphoma involve?

A

Jaw

22
Q

What does the sporadic form of Burkitt Lymphoma arise?

A

Abdomen

23
Q

Translocation of Burkitt Lymphoma

A

t(8;14) cMyc-IgH

24
Q

What is the function of cMyc?

A

Promotes cell growth

25
Q

What is the appearance of Burkitt lymphoma on histology?

A

“Starry sky” appearance due to the high mitotic rate - large blue area with white spots due to macrophage infiltration

26
Q

Diffuse Large B-cell Lymphoma

A

Neoplastic large sized B cells that are CD20+ and grow diffusely in sheets - aggressive

27
Q

What is the most common non-Hodgkin lymphoma?

A

Diffuse large B-cell lymphoma

28
Q

How can DLBCL arise?

A

Sporadically or as a transformation follicular lymphoma

29
Q

What does DLBCL present as and at what age?

A

Late adulthood as an enlarging LN or an extra nodal mass

Pathoma (119 decks)

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