13.2 Vagina

Question 1

Vaginal Adenosis

Answer 1

Focal persistence of columnar epithelium in the upper 2/3 of the vagina

Question 2

What is a risk factor for vaginal adenosis?

Answer 2

Exposure to DES in utero

Question 3

What does adenosis increase the risk for?

Answer 3

Clear Cell Vaginal Adenocarcinoma

Question 4

What cancer is the drug DES a risk factor for?

Answer 4

Clear Cell Vaginal Adenocarcinoma

Question 5

What is a structural complication of exposure to DES in utero?

Answer 5

It can lead to malformation of smooth muscle in the uterus and the tubes which leads to increased risk of infertility and ectopic pregnancy

Question 6

What do mothers who used DES have an increased risk of?

Answer 6

Breast Carcinoma

Question 7

Embryomal Rhabdomyosarcoma

Answer 7

Malignant mesenchymal proliferation of skeletal muscle that presents as a grape like mass

Question 8

What population is embryonal rhabdomyosarcoma often seen in?

Answer 8

Young children less than 5 yrs

Question 9

What will immunostain of rhabdomyoblasts show?

Answer 9

• Desmin

- Myogenin

Question 10

What is the precursor lesion of vaginal carcinoma?

Answer 10

VAIN (Vaginal Intraepithelial Neoplasia)

Question 11

Where does vaginal carcinoma in the upper 2/3 of the vagina spread?

Answer 11

Iliac Nodes

Question 12

Where does vaginal carcinoma in the lower 1/3 of the vagina spread?

Answer 12

Inguinal Nodes