15.11 Adrenal Medulla Flashcards
1
Q
What embryonic cells is the adrenal medulla derived from?
A
Neural Crest
2
Q
What does the adrenal medulla synthesize?
A
EPI and NE
3
Q
Pheochromocytoma
A
Tumor of chromaffin cells
4
Q
What is the appearance of the pheochromocytoma?
A
Brown Tumor
5
Q
What are the clinical features of pheochromocytoma?
A
- HTN
- Headaches
- Palpitations
- Tachycardia
- Sweating
6
Q
What is the breakdown product of EPI?
A
Metanephrine
7
Q
What is the breakdown product of NE?
A
Mermetanephrine
8
Q
What is the final breakdown product of EPI and NE?
A
VMA
9
Q
What are patients given before pheochromocytomas are removed?
A
Phenoxybenzamine - irreversible alpha adrenergic antagonist
10
Q
What is another location where pheochromocytomas can be found?
A
Wall of the bladder
11
Q
What are some associations with pheochromocytoma?
A
- MEN2A and 2B
- VHL Disease
- NF Type 1
