16.3 Breast Cancer

Question 1

What is the most common cancer in women outside of skin?

Answer 1

Breast Cancer

Question 2

What are some risk factors for breast cancer?

Answer 2

• Female
• Older age
• Early menarche
• Late menopause
• Obesity

Question 3

Ductal Carcinoma In Situ

Answer 3

Malignant cells in the duct bound by the basement membrane but that do not invade it

Question 4

Invasive Ductal Carcinoma

Answer 4

Malignant cells in the duct invade through the basement membrane and form duct like structures

Question 5

Comedo Type of DCIS

Answer 5

High grade cells with necrosis and dystrophic calcification in the center of ducts

Question 6

Paget Disease

Answer 6

DCIS that extends up the ducts to the skin of the nipple causing ulceration and erythema

Question 7

What is the most common type of invasive breast carcinoma?

Answer 7

Invasive Ductal Carcinoma

Question 8

Tubular Carcinoma

Answer 8

Tubules are produced with desmoplastic stroma with good prognosis

Question 9

Mucinous Carcinoma

Answer 9

Malignant cells in mucus that has excellent prognosis found in elderly women

Question 10

Inflammatory Carcinoma

Answer 10

Erythematous and swollen breast that shows cancer in the lymphatics of the breast - poor prognosis

Question 11

Medullary Carcinoma

Answer 11

High grade malignant carcinoma with inflammatory cells like lymphocytes and plasma cells

Question 12

What mutation is medullary carcinoma associated with?

Answer 12

BRCA-1 Mutation

Question 13

Lobular Carcinoma In Situ

Answer 13

Malignant proliferation of cells in lobules with no invasion of BM

Question 14

What is key that is lacking in LCIS?

Answer 14

E-cadherin

Question 15

Does LCIS produce masses or calcification?

Answer 15

No

Question 16

What is the treatment for LCIS?

Answer 16

Tamoxifen

Question 17

Invasive Lobular Carcinoma

Answer 17

Invade and grow in a single file pattern due to lack of E-cadherin

Question 18

What is the most important factor for prognosis of breast cancer?

Answer 18

Spread to lymph nodes

Question 19

What are ER and PR associated with?

Answer 19

Response to tamoxifen

Question 20

What is HER2/neu associated with?

Answer 20

Response to transtuzumab

Question 21

What is the prognosis of the triple negative ER/PR/HER2?

Answer 21

Poor

Question 22

What race has an increased risk of triple negative breast carcinoma?

Answer 22

African American women

Question 23

What can suggest hereditary breast cancer?

Answer 23

• Multiple tumors
• Family Hx
• Premenopausal presentation

Question 24

What does BRCA1 mutation increase risk for?

Answer 24

Breast and ovarian carcinoma

Question 25

What does BRCA2 mutation increase risk for?

Answer 25

Breast carcinoma in males

Question 26

Male Breast Cancer

Answer 26

Rare and presents as a subareolar mass and can cause nipple discharge

Question 27

What is the most common type of male breast cancer?

Answer 27

Invasive Ductal Carcinoma

Question 28

What other disease is male breast cancer associated with?

Answer 28

Klinefelter Syndrome