10.7 Inflammatory Bowel Disease

Question 1

Inflammatory Bowel Disease

Answer 1

Chronic relapsing inflammation of the bowel

Question 2

Who is the classical patient of IBD?

Answer 2

Young Caucasian woman

Question 3

What are the 2 types of IBD?

Answer 3

• Ulcerative Colitis

- Crohn’s Disease

Question 4

Wall Involvement of UC

Answer 4

Mucosal and submucosal ulcers

Question 5

Location of UC

Answer 5

Rectum up to cecum with rest of GI tract unaffected - it travels from the rectum up to a certain stop point and is continuous

Question 6

Symptoms of UC

Answer 6

LLQ pain with bloody diarrhea

Question 7

Gross Appearance of UC

Answer 7

Pseudo polyps with loss of haustra

Question 8

Complications of UC

Answer 8

• Toxic megacolon

- Carcinoma

Question 9

What is UC associated with?

Answer 9

Primary Sclerosing Cholangitis and p-ANCA positivity

Question 10

What is the effect of smoking on UC?

Answer 10

Smoking protects against UC

Question 11

Wall Involvement of Crohn’s

Answer 11

Full transmural inflammation with knife like fissures

Question 12

Location of Crohn’s

Answer 12

Anywhere from mouth to anus with skip lesions with terminal ileum as the most common site

Question 13

Symptoms of Crohn’s

Answer 13

RLQ pain with non bloody diarrhea

Question 14

Gross Appearance of Crohn’s

Answer 14

Cobblestone mucosa with creeping fat and strictures

Question 15

Complications of Crohn’s

Answer 15

Malabsorption with nutritional deficiency and formation of fistulas

Question 16

What is Crohn’s associated with?

Answer 16

• Ankylosing Spondylitis
• Sacroilitus
• Calcium Oxalate Nephrolithiasis
• Migratory Polyarthritis
• Erythema Nodosum

Question 17

What is the effect of smoking on Crohn’s?

Answer 17

Increases risk for Crohn’s

Question 18

What is the hallmark of UC?

Answer 18

Neutrophils in the crypts

Question 19

What is the hallmark of Crohn’s?

Answer 19

Lymphoid aggregates with granulomas

Question 20

Why do strictures form in Crohn’s?

Answer 20

Transmural inflammation with fissures leads to fibrosis and contraction healing