6.7 Hodgkin Lymphoma

Question 1

Hodgkin Lymphoma

Answer 1

Rare amounts of Reed-Sternberg cells that cause neoplastic proliferation of large B cells with CD15+ and CD30+

Question 2

What does a Reed-Sternberg cell look like?

Answer 2

“Owl eyes”

Question 3

What is the action of the Reed-Sternberg cells?

Answer 3

Secrete cytokines that attract lymphocytes, plasma cells, macrophages and eosinophils

Question 4

What makes up the bulk of a Hodgkin lymphoma tumor?

Answer 4

Inflammatory cells

Question 5

What is the most common type of Hodgkin lymphoma?

Answer 5

Nodular Sclerosis

Question 6

Hodgkin lymphoma - Nodular Sclerosis typical presentation and patient

Answer 6

Young female with an enlarging cervical neck LN

Question 7

What is the histology of nodular sclerosis?

Answer 7

Lymph node divided by bands of fibrosis with lake-like spaces of lacunar cells - Reed Sternberg cells sit in the lakes and are called lacunar cells

Question 8

Which of the Hodgkin lymphoma subtypes has the best prognosis?

Answer 8

Lymphocyte rich

Question 9

Which of the Hodgkin lymphoma subtypes has the worst prognosis?

Answer 9

Lymphocyte depleted - in the elderly and HIV patients

Question 10

What is associated with mixed cellularity Hodgkin lymphoma?

Answer 10

Eosinophils and IL-5