56. Ischemic Heart Disease 52% Flashcards

1
Q

Describe diagnosis of ischemic heart disease (2)

A
  • Ischemic heart disease diagnosis is based on pretest probability (symptoms, risk, noninvasive testing)
  • CAD diagnosis is established if history of ACS or presence of obstructive lesions on angiography
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2
Q

Describe : Classical chest pain (4)

A
  • Dull RSCP (discomfort, heaviness, aching, pressure; not changing in intensity with inspiration, cough or position change; with or without radiation into jaw, neck, shoulders, arms)
  • Provoked by exertion or emotional stress (lying down, post-prandially)
  • Relieved within <5 min by rest or Nitroglycerin.
  • Non-classical symptoms might include: shortness of breath, N/V, diaphoresis, fatigue, dizziness
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3
Q

Which population should we look out for that may present with ATYPICAL chest pain ? (4)

A
  • Women
  • Those with DB
  • Young
  • Those at no risk
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4
Q

Describe : Atypical chest pain in DM, women, patients without risk factors (eg. young) (3)

A
  • New CP
  • Duration >20 min
  • Occurrence at rest
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5
Q

Name modifiable risk factors (9)

A
  • Smoking
  • DLP
  • DM2
  • CKD
  • HTN
  • Obesity or Metabolic syndrome
  • Physical Inactivity
  • Diet
  • Depression
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6
Q

Name non-modifiable risk factors (4)

A
  • Age
  • Sex (male)
  • Ethnicity (Hispanic, Native American, African American, Asian)
  • Family history of premature CVD (1st degree relative, <55yo men, <65yo women)
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7
Q

Name CV Co-morbidities (4)

A
  • Maladie valvulaire
  • Maladie cérébrovasculaire
  • Maladie vasculaire périphérique
  • Maladie rénale
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8
Q

Name investigations : Ischemic heart disease (7)

A
  • 12-lead ECG
  • Hemoglobin
  • Full lipid panel (Total cholesterol, LDL, HDL)
  • Fasting blood glucose or HbA1c
  • Creatinine
  • AST, ALT, Total Bilirubin
  • TSH
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9
Q

Name findings consistent with CAD in EKG (5)

A
  • Evidence of left ventricular hypertrophy
  • ST-T wave changes consistent with ischemia
  • Previous Q-wave myocardial infarction (MI)
  • Bundle branch block
  • Conduction/rhythm disturbances
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10
Q

Name Choice of non-invasive testing (2)

A
  • Exercise ECG test preferred if able to exercise and interpretable ECG
  • Alternatives to exercise include vasodilators and cardiac stimulants
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11
Q

Name invasing testing (1)

A

L’angiographie coronaire (ou coronarographie)

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12
Q

Name vasodilators agents for non-invsaive testing (3)

A
  • adénosine
  • dipyridamole
  • régadénoson
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13
Q

Name cardiac stimulants agents for non-invsaive testing (1)

A

dobutamine

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14
Q

Invasive testing (coronary angiography) indicated if what ? (5)

A
  • High pretest probability of stable ischemic heart disease
  • High-risk features on non-invasive testing
  • Persistent symptoms or inadequate QOL despite optimal medical treatment
  • History of ACS
  • Life-threatening arrhythmias
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15
Q

Describe counselling in management of stable disease (9)

A
  • Review treatment options, Medication adherence for symptom relief and prevent disease progression
    Explanation of CV risk
  • Treat any concurrent DM2 or DLP or HTN
  • Lifestyle
  • Smoking cessation
  • Weight loss
  • Diet (high intake of vegetables, whole grains, fresh fruit; reduce salt, saturated/trans fat)
  • Physical activity (150 min/week of moderate or vigorous activity)
  • Assess and manage stress/depression
  • Red flags when to seek medical care
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16
Q

Describe tx to improve prognosis in stable disease (4)

A
  • ASA 81mg (or Clopidogrel 75mg if ASA intolerance)
  • High-intensity Statin (eg. Rosuvastin 20-40mg daily, Atorvastatin 80mg daily)
  • ACEI (or ARB) if HTN, DM2, CKD, left ventricular ejection fraction ≤ 40%
  • Revascularization therapy (PCI or CABG) in patients who underwent coronary angiography
17
Q

Describe symptomatic relief in tx stable disease (2)

A
  • Nitroglycerin (short-acting) 0.4mg SL tab or spray q5 mins PRN, seek prompt medical attention if pain persists after 3 doses
  • Beta-blockers especially if prior MI, HF, LVEF ≤ 40%, eg. Bisoprolol, target HR 55-60 bpm
18
Q

If cannot tolerate BB or symptomatic on monotherapy, what to do ?

A

start/combine
* Long-acting CCB (eg. Amlodipine or Diltiazem). Avoid non-dihydropyridine CCB in combination with BB if risk of AV block and excessive bradycardia
* Nitroglycerin transdermal patch 0.2mg/hour titrate up to 0.8mg/hour (remember to remove patch 12-14h, eg. apply 8AM-8PM)

19
Q

Describe what to evaluate during follow-ups

A

HPI
* Severity and progression of symptoms
* Impact on daily function and QOL, NYHA Class I-IV
* Complications of CAD (arrhythmia, heart failure, ACS)
* Medication compliance, appropriate use of medication (Nitro SL prn)

Physical exam
* Cardio exam (BP, HR, S4, murmur, bruit)
* Resp exam (crackles)

Investigations
* ECG if symptom change or annually
* Routine CBC, creat, FBG/HbA1c, lipids

Management
* Counselling as above
* Optimize medication
* Cardiac rehab program, especially s/p revascularization

20
Q

Comment confirmer DX si : Si pt capable de faire effort et ECG au repos N

A

Épreuve d’effort (EE)

21
Q

Comment confirmer DX si : Si pt pas capable de faire effort ou ECG repos anormal

A
  • Mibi-dypiridamole (BBG ou rythme ventriculaire pmp)
  • ou écho- effort
  • ou Mibi d’effort
  • ou angiographie par TDM
22
Q

Si EE négatif, est-ce que l’angine est éliminé?

A

bon facteur pronostic, mais n’élimine pas l’angine

23
Q

Vrai ou Faux
EE positif avec certains facteurs de mauvais pronostic peuvent justifier coronarographie

A

Vrai
(ischémie précoce < 3min., ischémie persistante < 3min en récupération, sous décalage SST < 2mm, faible tolérance à l’effort, apparition d’arythmie ventriculaire en récupération)

24
Q

Nommez C-I EE (11)

A
  • sténose aortique sévère
  • HTP sévère
  • IM < 2 jours
  • angine instable
  • instabilité HD
  • endocardite
  • péricardite
  • myocardite
  • embolie
  • suspicion de dissection aortique
  • condition pouvant s’exacerber à l’effort
25
Q

Contre-indication au Mibi-dipyridomale (5)

A
  • bronchospasme
  • BAV haut grade
  • sténose artères rénale
  • hypoTA
  • sick sinus syndrome sévère
26
Q

Nommez C-I : Angiographie par TDM

A

si fonction rénale ne permet pas de contraste

27
Q

Nommez indications de coronarographie (9)

A
  • Histoire de mort subite
  • Angor instable
  • NSTEMI
  • Angor avec insuffisance cardiaque symptomatique
  • Occupation nécessitant dx définitif
  • Hospitalisations récurrentes pour DRS
  • Haute probabilité clinique MCAS sévère
  • Examen non invasif suggérant mauvais pronostic
  • Angor persistant malgré traitement médical chez patient avec test non invasif de bon pronostic
28
Q

Décrire comment éduquer le patient sur les raisons de consultations à l’urgence (3)

A
  • ddlr malgré repos < 20min
  • angor crescendo ou de novo survenant au moindre effort
  • angor avec syncope/dyspnée ou OMI
29
Q

Nommez les artères atteintes selon les territoires
* Ant
* Lat
* Inf

A
  • Ant : IVA
  • Lat : circonflexe
  • Inf : coronaire droite