56. Ischemic Heart Disease 52% Flashcards

1
Q

Describe diagnosis of ischemic heart disease (2)

A
  • Ischemic heart disease diagnosis is based on pretest probability (symptoms, risk, noninvasive testing)
  • CAD diagnosis is established if history of ACS or presence of obstructive lesions on angiography
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2
Q

Describe : Classical chest pain (4)

A
  • Dull RSCP (discomfort, heaviness, aching, pressure; not changing in intensity with inspiration, cough or position change; with or without radiation into jaw, neck, shoulders, arms)
  • Provoked by exertion or emotional stress (lying down, post-prandially)
  • Relieved within <5 min by rest or Nitroglycerin.
  • Non-classical symptoms might include: shortness of breath, N/V, diaphoresis, fatigue, dizziness
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3
Q

Which population should we look out for that may present with ATYPICAL chest pain ? (4)

A
  • Women
  • Those with DB
  • Young
  • Those at no risk
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4
Q

Describe : Atypical chest pain in DM, women, patients without risk factors (eg. young) (3)

A
  • New CP
  • Duration >20 min
  • Occurrence at rest
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5
Q

Name modifiable risk factors (9)

A
  • Smoking
  • DLP
  • DM2
  • CKD
  • HTN
  • Obesity or Metabolic syndrome
  • Physical Inactivity
  • Diet
  • Depression
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6
Q

Name non-modifiable risk factors (4)

A
  • Age
  • Sex (male)
  • Ethnicity (Hispanic, Native American, African American, Asian)
  • Family history of premature CVD (1st degree relative, <55yo men, <65yo women)
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7
Q

Name CV Co-morbidities (4)

A
  • Maladie valvulaire
  • Maladie cérébrovasculaire
  • Maladie vasculaire périphérique
  • Maladie rénale
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8
Q

Name investigations : Ischemic heart disease (7)

A
  • 12-lead ECG
  • Hemoglobin
  • Full lipid panel (Total cholesterol, LDL, HDL)
  • Fasting blood glucose or HbA1c
  • Creatinine
  • AST, ALT, Total Bilirubin
  • TSH
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9
Q

Name findings consistent with CAD in EKG (5)

A
  • Evidence of left ventricular hypertrophy
  • ST-T wave changes consistent with ischemia
  • Previous Q-wave myocardial infarction (MI)
  • Bundle branch block
  • Conduction/rhythm disturbances
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10
Q

Name Choice of non-invasive testing (2)

A
  • Exercise ECG test preferred if able to exercise and interpretable ECG
  • Alternatives to exercise include vasodilators and cardiac stimulants
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11
Q

Name invasing testing (1)

A

L’angiographie coronaire (ou coronarographie)

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12
Q

Name vasodilators agents for non-invsaive testing (3)

A
  • adénosine
  • dipyridamole
  • régadénoson
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13
Q

Name cardiac stimulants agents for non-invsaive testing (1)

A

dobutamine

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14
Q

Invasive testing (coronary angiography) indicated if what ? (5)

A
  • High pretest probability of stable ischemic heart disease
  • High-risk features on non-invasive testing
  • Persistent symptoms or inadequate QOL despite optimal medical treatment
  • History of ACS
  • Life-threatening arrhythmias
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15
Q

Describe counselling in management of stable disease (9)

A
  • Review treatment options, Medication adherence for symptom relief and prevent disease progression
    Explanation of CV risk
  • Treat any concurrent DM2 or DLP or HTN
  • Lifestyle
  • Smoking cessation
  • Weight loss
  • Diet (high intake of vegetables, whole grains, fresh fruit; reduce salt, saturated/trans fat)
  • Physical activity (150 min/week of moderate or vigorous activity)
  • Assess and manage stress/depression
  • Red flags when to seek medical care
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16
Q

Describe tx to improve prognosis in stable disease (4)

A
  • ASA 81mg (or Clopidogrel 75mg if ASA intolerance)
  • High-intensity Statin (eg. Rosuvastin 20-40mg daily, Atorvastatin 80mg daily)
  • ACEI (or ARB) if HTN, DM2, CKD, left ventricular ejection fraction ≤ 40%
  • Revascularization therapy (PCI or CABG) in patients who underwent coronary angiography
17
Q

Describe symptomatic relief in tx stable disease (2)

A
  • Nitroglycerin (short-acting) 0.4mg SL tab or spray q5 mins PRN, seek prompt medical attention if pain persists after 3 doses
  • Beta-blockers especially if prior MI, HF, LVEF ≤ 40%, eg. Bisoprolol, target HR 55-60 bpm
18
Q

If cannot tolerate BB or symptomatic on monotherapy, what to do ?

A

start/combine
* Long-acting CCB (eg. Amlodipine or Diltiazem). Avoid non-dihydropyridine CCB in combination with BB if risk of AV block and excessive bradycardia
* Nitroglycerin transdermal patch 0.2mg/hour titrate up to 0.8mg/hour (remember to remove patch 12-14h, eg. apply 8AM-8PM)

19
Q

Describe what to evaluate during follow-ups

A

HPI
* Severity and progression of symptoms
* Impact on daily function and QOL, NYHA Class I-IV
* Complications of CAD (arrhythmia, heart failure, ACS)
* Medication compliance, appropriate use of medication (Nitro SL prn)

Physical exam
* Cardio exam (BP, HR, S4, murmur, bruit)
* Resp exam (crackles)

Investigations
* ECG if symptom change or annually
* Routine CBC, creat, FBG/HbA1c, lipids

Management
* Counselling as above
* Optimize medication
* Cardiac rehab program, especially s/p revascularization