Diabetes Pharmacology

Question 1

when do glucose and insulin levels peak after a meal?

Answer 1

around 60 min

Question 2

which pt has to secrete more insulin in order to maintain stable glucose levels?

Answer 2

obese pts

Question 3

how long do you try a therapy before changing it, typically?

Answer 3

2-3 months

Question 4

what are the primary goals of diabetic therapy?

Answer 4

1. reduce risk of acute and chronic complications
2. foster adherence
3. limit side effects
4. limit cost

Question 5

when using dual or triple therapy, what should you do?

Answer 5

choose two drugs that do different things

Question 6

what is a common first line med for DM?

Answer 6

metformin

Question 7

when does metformin cause lactic acidosis?

Answer 7

drug is excreted in whole by the kidneys and if it hangs around, it will inhibit hepatic metabolism of lactic acid (60% mortality)

Question 8

what is glucagon like peptide?

Answer 8

hormone released by the gut in response to glucose ingestion

Question 9

what does glucagon-like peptide do?

Answer 9

stimulated insulin synthesis and secretion
suppresses glucagon secretion
reduces islet cell apoptosis

Question 10

how is GLP 1 broken down?

Answer 10

DPP-IV

Question 11

how do GLP levels change in type II diabetics?

Answer 11

decreased levels

Question 12

what does DPP-IV do?

Answer 12

inactivates GLP 1