Wed Wk 6 Mixed 4 Flashcards

1
Q

__ is anti-inflammatory cytokine
stops __ response and inhibits MHC class 2 expression
stops / and supports humoral immuity

TCA drugs inhbit NE/Serotonin reuptake and can lead to /

light microscopy of VZV shows __ inclusions in keratinocytes
Multinucleated __ w acantholysis

acantholysis w suprabasal blisters is __
eosinophilic cytoplasmic inclusions is -_
cytoplasmic vacuoles in keratinocytes/koilocytosis w hyperplasia is __

A

IL10
Th1
macros/DC

tremor/insomnia

intranuclear
giant cells
PV
pox virus
HPV
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2
Q

complete mole has __ in 1st trimester
uterus is __ w very high BHCG
leads to H and preeclampsia, hyperthyroid and __ cyst
see __ troph prolif w edematous villi (bunch of grapes)
no __ tissue
stains p57 __

Partial mole has vag bleeding and __ ab pain
uterus is _ w normal/high BHCG
some enlarged villi w __ proliferation
p57 is __

sarcoma butyroides is __ in young girls
see __ at bladder/vaginal mucosa

most important factors for hypogly in T1DM is excessive __ or inadeqaute __ or __

A
vaginal bleeding
ENLARGED
hyperemesis gravidarum
theca lutein
diffuse
fetal
negative
crampy
normal
focal
positive
rhabdomyosarcoma
jelly like cyst

insulin, intake, exercise

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3
Q

GLUT4 can be translocated to cell membrane in __
pt on insulin is vulnerable to hypoglycemia as insulin __ to be released despite drop in glucose
exercise may change skin _ that aids in insulin uptake, exacerbating absorption

SNS activation typically leads to __

__ in NF1 cause visual loss
__ is hamartoma of eye iin NF1
also have __ abnorms and CNS tumors

gallstone ileus occurs due to __ fistula
look for air in __
charcot triad indicates __

A

muscle contraction
continues
perfusion

hyperglycemia

optic gliomas
lisch nodules
bone

cholecystoenteric fistula
biliary tree
ascending cholangitis

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4
Q

spinal cord ends at __ in adults
__ of spinal cord extends to form filum terminale, connecting conus medullaris to posterior __
dura ends at __ and fuses w filum terminale to form posterior coccyx
insert LP into / spaces
L4 VERTEBRAL BODY IS LOCATED at highest point of __
PSIS located at __ level

__ is invagination of sarcolemma in striated muscle
has L type Ca channels that allow for __ to rapidly propagate through the muscle fiber
ensures that Ca release from SR is __ in each muscle
uncoordinated contraction manifests as __

most common mode of HBV transmission is __

A
pia mater
coccyx
S2
L3/L4 or L4/L5
ILIAC CREST

S2

Transverse tubules
depolarization
uniform
syncronized contraction

sexual

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5
Q

Leg swelling, orthopnea is potential SE of D
Dry cough/exertional SOB is SE of B
Tarry stool/fatigue caused by chemo agents that affect __ dividing cells
usually due to __ agent
Ab pain/cholestasis and hepatitis are comps of __

AV fistula has __ mass w thrill on palpation w bruit
allow blood to go from arteries to veins, bypassing __ which is main source of resistance
thus, LV afterload is __
leads to high output __

communicating hydrocephalus has _ ventricles enlarged
due to disruptions of __
usually due to __ or hemorrhae

A
doxorubicin
bleomycin
rapidly
alkylating
mercaptopurine

palpable
arterioles
LOWERED
cardiac failure

all 4
arachnoid granulations
infection

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6
Q

in all types of placental injury, DIC IS MEDIATED BY __ to initiate coag cascade
vaginal bleeding, uterine tenderness, hematoma and fetal demise is placental __
assc w __

AFE assc w hypoTN and __
uterine rupture occurs w previous uterine __
see vaginal bleeding, acute ab pain, loss of fetal __
palpable fetal parts in __

__ breathing is cyclic pattern w inc/dec TV
seen in pt w __ and leads to hyperventilation w hypopcapnia
leads to __ during sleep when CO2 falls below certain level
w prolonged circulation bw lungs/brain, abnormal _ is sensed by alveoli/medullda
also seen in __ disease

deep labored breathing is _
OSA has normal _ even in non-apneic periods w minimal variation in TV

A

TISSUE FACTOR
abruption
HTN

cardiogenic shock
surgery
station
myometrium

Cheyne stokes
CHF
apnea
PaCO2
CNS

kussmaul breathing
VENTILATION

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7
Q

Cholera is extremely __ sensitive
thus, if pt has reduced __ secretion, it is much easier for pt to become infected

pt w HCM has LVOT that is worse w __
thus avoid __ and __
_/__ and disopyramide are preferred

cAMP activates _ that can inhibit platelet aggregation
drugs that inc cAMP prevent plate __ change and granule release
thus, use C_ to inhibit phosphodiesterase and act as arterial vasodilator
Pt w PAD also needs / to reduce risk of thromboembolic events

hydatidiform mole due to overexpression of __ genes
becomes __ when villi invade myometrium (both invasive/complete have __ enlarged hydropic villi)

choriocarcinoma presents w vaginal bleeding and __

A

ACID
ACID SECRETION

volume depletion
VASODILATORS, DIURETICS
BB/NDCCB

PKA
shape
cilostozol
aspirin/clopidigrel

parental
invasive
diffusely

pulm manifestations

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8
Q

Avitaminosis A can lead to __ of epithelial lining of pancreatic exocrine ducts
normal levels are needed for __ of specialized epithelium such as mucus secreting columnar epithelium

infection of face enters cavernous sinus via _ facial vein system of S/I OV
sx include loss of all __
may affect CNV and its __ provision to face/corneal reflex
may have P/C due to impaired venous drainage

NPH due to \_\_ of arachnoid granulations
\_\_ difficulties appear first, alongside UMN signs
then \_\_ disturbs and urge incontinence
look for \_\_ w/out sulci enlargement
also for sx improvement upon \_\_
A

keratinizing squamous metaplasia
differentiation

valveless
EOM
sensory
proptosis, chemotosis

scarring

scarring
gait
cognitive

ventricular enlargement
CSF removal

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9
Q

Chancroid due to __
multiple, deep __ ulcers w gray/yellow base
gram stain shows __

Genital herpes have multinucleated giant cells w __ inclusions (Cowdry bodies)

__ due to Klebsiella granulomatis
extensive/progressive _ w out LAD/pain
see __ like tissue
deeply staining gram neg intracytoplasmic __ called donovan bodies
can lead to scarring/strictures w severe __ obstruction and lymphedema

Lymphogranuloma venereum due to C trach __
small, shallow painless __
large, painful Inguinal __/__
intracytoplasmic chlamydial _ in epithelial/leuks
may lead to F/lymph obstruction and fistulas

A

H ducreyi
painful
school of fish

intranuclear

Granuloma inguinale
ulceration
granulation 
cysts
lymphatic
L1-L3
ulcers
LAN/buboes
inclusion bodies
fibrosis
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10
Q

HCM due to systolic, anterior motion of __ toward IV septum
leads to __ and LVOT
see crescendo/decrescendo murmur located at /

craniopharyngioma is __ w solid areas
cysts filled w fluid composed of __ and cholesterol crystals
see dystrophic __ w strat squamous epithelium

scleroderma has upregulation of __ w progressive tissue fibrosis
leads to esophageal dysmotility w atrophy and __ replacement of muscularis in LES
leads to dilated LES w inc risk of /

__ is periodic, uncoordinated contractions of LES due to impaired __ innervation in myenteric plexus

A

MV
severe mitral regurgitation
LLSB/Apex

cystic
proteins
calcification

fibroblasts
fibrotic
GERD/strictures

Diffuse esophageal spasm
inhibitory

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11
Q

high levels of __ lead liver to produce APR
ESR places whole blood in tube that __ at bottom of tube over time
meausre of length of plasma on top after __
presence of APR like __ causes RBC to form rouleaux
this inc settling and __

larger VSD allow for __ of chamber pressures w dec LV spO2

bifid carotid pulse w brisk upstroke is __

fatigue/heart palpitations are common manifestations of __

anemia of chronic disease may have __

A
IL6
sediments
1hr
FIBRINOGEN
ESR

HCM

anemia

target cells

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12
Q

AE of ergosterol due to its ability to bind __
can have __ reactions
prevent w anti __/__
Nephrotoxicity due to dec in __, thus limit renal toxic drugs
monitor __ daily (K/Mg)
Anemia esp w hiv pt taking Z

pt w ovarian cancer presents w pelvic mass, A/P w appetite change, distension/bowel change
think __ ovarian cancer w anaplasia and stomal invasion, multiple papillary formations and psammoma bodies
CA-125 will be __

A
cholesterol
injection site
pyretics/histamines
GFR
Electrolytes
ziduvidine
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13
Q

Epithelial: Serous cystadenoma is __ w Psammoma bodies
Mucinous: has P w mucin producing epithelial cells

Germ cell: Dysgerminoma more common in __
secretes /
histology is __
Yolk sac endodermal has high __ w __ resembling glomeruli

Sex cord: Granulosa secretes __ and __
See call exner bodies and __ nuclei
Sertoli leydig has high __ and looks like S/L cells

A

bilateral
pseudomyxoma peritonei

adolescents
BHCG, LDH
fried egg
AFP, schiller duval bodies

Estrogen/Inhibin
coffee bean
androgens

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14
Q

venous blood of legs goes from __ to deep veins to IVC
w high pressures, veins __ w incompetent valves
allows __ flow into superficial veins w high pressure

leads to ischemia and venous stasis __
extravasation of RBC leads to __ and brawny color
RF include obstruction via O/P, or chronic damage to valves DVT

Lymphedema is __ due to fibrosis/thickening of skin

A

superficial
dilate
retrogade

dermatitis
iron deposition
obesity, pregnancy

nonpitting

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