Thurs Wk 6 Mixed Flashcards
__ has recurrent sinopulm infections, cancer, telangectasias, cerebellar atrophy
due to hypersensitivity to __
Fanconi anemia has deficiency of __ repair
generalized chromo instability is __
examples of orgs w low infectious dose include S, C, E, G
HUNTINGTON DISEASE IS __ MUTATION IN Polyglutamine region
thought to cause increased __
leads to high amount of __
think __ poisoning in pt w neuro regression and anemia
children have impaired __ thus lead is neurotoxic
see high zinc __ levels w high ALA levels
defect in __ causes PCT
see chronic __ w high uroporphyrinogen in urine
Ataxia telangectasia
ionizing radiation
CROSS LINK
Bloom syndrome
shigella, campylobacter, entamoeba, giardia
GAIN OF FUNCTION
TRANSCRIPTION REPRESSION
histone deacetylation
LEAD
BBB
protoporphyrin
uroporphrinogen decarboxylase
PHOTOSENSITIVTY
Diabetes insipidus leads to low specifc gravity and urine __
partial NDI and primary polydipsia will have urine osmolarity that __ w water deprivation test
Listeria has very narrow __ on blood agar like GBS
HMG CoA reductase increases __ to allow intrahepatic cholesterol levels to remain normal
SMA connected to IMA via anastamoses like __ artery of drummond, and possible mesenteric meandering artery
protects intestines from __
elderly pt w fatigue, weakness, itching due to accumulation of __ toxins in CKD
hyaline material in small ateries/arterioles indiates __ arteriolosclerosis
can be seen w uncontrolled __/__ due to hemodynamic stress and SMC prolif
osmolality
RISES
beta hemolysis
receptor recycling
marginal
ischemia
uremic
hyaline
HTN/DM
Malignant HTN has __ necrosis w destrxn of vascular wall w pink, amorphous material in lumen
see concentric __ of walls due to laminated SMC
think __ w obstructing tubular casts
in hypoxic conditions, accumulation of __ inhibits pyruvate dehydro
__ can regenerate the NAD+
pts w severe asthma require __ to control sx
Leukotriene antags, __ are not effective
can use O_ a humanized IgG1 monoclonal antibody against IgE to inhibit the high IgE levels in body
entrapment of __ w orbital floor damage causes impaired upward gaze
fibrinoid
narrowing
MULTIPLE MYELOMA
NADH
Lactate
oral corticosteroids
theophylline
omalizumab
inferior rectus
Hematoma over mastoid process indicates __ fracture
MCC of HIV assc esophagitis is //_
Candida has patches of grey/white __ on erythematous mucosa
microscopy shows __
CMV shows large, shallow __
intranuclear & intracytoplasmic __
HSV1 has small __ w punched out ulcers
see eosinophilic __ inclusions w multinucleated squamous cells
M/H anemia w low __ is iron deficiency anemia
pt w VWF have easy bleeding from / sites
isolated thrombocytopenia w episodic mucocutaneous bleeding is __
Protein C binds thrombin w endothelial __
basilar skull
Candida, CMV, HSV pseudomembranes linear ulcers inclusions vesicles intranuclear
skin/mucosal
FERRITIN
skin/mucosal
ITP
thrombomodulin
OCP also inc __ synthesis by liver, dec free testosterone levels
orbit bound superiorly by _
laterally by __/__
inferirly by __
medially by __/__
antiphospholipid syndrome has __ state due to activation of phosholipid depend coag pathways
see anticardiolipin and anti-beta2-__ 1 antibody
Adiponetic is released by __ drugs to inc number of insulin responsive adipocytes
__ binds to sulfhydryl groups to impair cell respiration by inhibiting pyruvate dehydrogenase
acquired via __ or contaminated water
disrupts __ leading to GARLIC breath, vomiting, watery diarrhea, QTC prolongation (TdP) and __
can cause hypo/hyper_ w neuropathy
tx w __ or DMSA
SHBG
frontal bone
zygoma/sphenoid
maxilla
ethmoid/lacrimal
hypercoagulable
glyoprotein
arsenic insecticides gluconeogenesis hypoTN pigmentation DIMERCAPROL
Lead poisoning antidote is __ to form salts to inc excretion
use __ to chelate iron for urinary excretion
__ poisoning has cherry red skin color w ab pain, vomiting
tx w __ to inc urinary excretion
__ used for Methemoglobinemia
see skin discoloration, SOB and __ blood
Statins/bile acid resins have __ effect when used togetehr
annular scaling plaque w defined raised borders/central clearing is _
use __ to inhibit squalene epoxidase
drug accumulates in __
hypopotuitarism can be caused by lymphocytic lesion to __
or hypothalamic lesions by / and radiation
__ deficiency has hypoTN, WL and hypoglycemia
CaNa2EDTA
deferoxamine
cyanide
hydroxycobalamin
Methylene blue
chocolate colored
synergistic
TINEA CORPORIS
terbiafine
skin
AP
sarcoid/histiocytosis X
ACTH
pt w panhypopituitarism, failed lactation, central hypothyroid and adrenal insufficency has __
pituitary enlarges during pregnancy w __ induced hyperplasia of lactotrophs
__ does not change, thus becomes susceptible to hypoTN from peripartum hemorrhage and ischemia
normal bone marrow has 1:1 ratio of __ to hematopoeitc elements
__ is absent due to lack of hematopoeitic precursors/extramedullary hematopoeisis
may be caused by B/C/V
__ syndrome has hypercellular BM w abnormally differentiated cells
pleural plaques of __ usually found in parietal pleura
__ is toxic product of combustion that puts workers at risk
SHEEHAN SYNDROME
estrogen
blood supply
fat
HSM
benzene, carbamazepine, virus
myelodysplastic
asbesotis
NO2
CD can also lead to __/__ of perianal region
__ most common cause of malignant acanthosis nigricans in middle age/elderly pt
dec breath sounds, hemithorax opacification, deviation of trachea toward involved side indicate __
usually occurs in __ w atelectasis
loss of air and shifting of __ leads to complete hemithorax opacification
PE can have area of lucency w dec __
or __ shaped opacity adjacent to the pleura
pleural effusion/PTX has trachea deviate __
skin tags/fissures
complete obstruction of bronchus
mainstem bronchus
organs
perfusion
wedge
opposite
Cardiac/smooth myocyte depolarization activates __in PM to cause EC calcium to influx
activates __ to release Ca from SR (Ca induced Ca release)
in skeletal muscle, L type Ca channel bind __
this releases calcium from _
due to mechanical __ or receptors that does not require EC CALCIUM
Verapamil affects __ in cardiac/smooth muscle
does not affect __ as it does not depend on EC Ca influx
__ is hypo/hyperpigmented patches on body
due to __ YEAST
infection is in __ of skin in hot/humid climates after tanning
skin scraping shows spores/hyphae w __ appearnace
tx w topical __ or selenium shampoo
necrotizing, abscess forming PNA due to S/K/E/P
L tyep Ca channels Ryanodine receptors Ryanodine Ca channels directly SR coupling L type calcium channel skeletal muscle
pityriasis VERSICOLOR
MALASSEZIA
spaghetti/meatball
antifungals
staph, klebsiella, e coli, pseudomonas
total O2 content in blood determined by __ and SaO2
changes in __ is more influential on O2 content of blood
if PaO2/SaO2 are normal, dec O2 content must be due to low __
w cyanide poisoning, arterial //_ are NORMAL
venous O2 __ as OP is inhibited by binding of __ in cytochrome c oxidase
RtL sends __ to left heart, thus PaO2/SaO2 in periphery is low
CO poisoning leads to __ PaO2, dec __ and __
use __ benzo like lorazapem w rapid onset of action
Hb SaO2 HEMOGLOBIN PaO2/SaO2/O2 content is higher Ferric Fe3+ deoxygenated blood
normal, SaO2/O2 content
prsynaptic voltage gated __ promote vesicle fusion and NT release
can be blocked w __ to dec excitatory NT release
generalized, red breast tissue that is itchy is __ rash
skin is firm, coarse w breast __
this is __ cancer
due to cancer cells obstructing __ and spread to dermal lymph spaces
lack of fever differentiates it from __
DCIS has central __ confined to ducts/lobules
__ is eczematous nipple lesion
extension of __ to ducts
these are __ cancers
invasive
__ has nests/cords of cells
__ has small cells in single file w mammary stroma invasion
Ca
Gabapentin
peau d orange edema INFLAMMATORY BREAST lymphatic flow mastitis
necrosis
Paget dz of breast
DCIS
noninvasive
ductal carcinoma
lobular carcinoma
asthma is bronchial __ to trigger
could be __ cockroaches, pet dander, mold/pollen
due to allergens interacting w __ bound to mast cells w release of eosinophils
other triggers include S/P/I/B/E/G
/ can inhibit COX1 to precipitate asthma
NOT __ as it weakly inhibits COX
inhalational exposure to thermophilic actinomycetes is __
after expsure to __/__
hyperresponsiveness
dust mites
IgE
smoke, perfume, infection, bb, exercise, GERD
ASPIRIN/NSAIDs
ACETAMINOPHEN
hypersensitivity pneumo
hay/compost
