Friday Wk 4 Mixed 3 Flashcards

1
Q

lumpy bumpy appearance on IF is __
electron micro shows IC on __ side of BM

Dec ADAMTS13 is seen in __
uncleaved vWF __ w platelet trapping/activation
tx w __ exchange and GC/rituximab

DCCB cause edema due to inc capillary __ pressure
also seen in impaired venous return like __ side HF and VTE
Dec plasma oncotic pressure leads to __
dependent on __ level
high Na/Water retention leads to edema by diluting __
L__ obstruction precipitates edema

Edema only develops when resorptive capacity of __ tissues are overwhelmed

A

PSGN
epithelial

TTP
multimers
plasma

hydrostatic
Right
edema
albumin
plasma proteins
lymphatic

lymphatic

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2
Q

PMN chemotactic agents include C5a, IL8, LB4 and 5__
C5a activates PMN, and M/E/B

infantile __ has CV sx w cyanosis/SOB/vomiting
Dry beriberi is _ sx
wet adds __ sx

HBsAg presence in hepatocytes shows granular, diffusely homogenous, pale __ cytoplasm (ground glass hepatocyte)
also look for M__ inclusions and acidophil bodies w balloon __

clumped, amorphous, eosinophilic intracytoplasmic inclusions of tangled intermedite filaments is _ body seen in alcohol hepatitis

strep agalactiae is CAMP pos in that it __ S aureus hemolysis

A

HETE
monocytes, eosinophils, basophils

Beriberi
PN
cardiovascular

eosinophilic
mononuclear
degeneration

Mallory

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3
Q

pyruvate must become __ via PC using acetyl coa

both lactate/alanine are released into bloodstream to go to __ and become glucose

T__ is necessary for eversion/dorsiflexion
T__ is necessary for foot inversion
G/S__ needed for plantar flexion

t1/2= .7 x Vd
CL

reproductive system differentiation goes w G to G to E development

A

oxaloacetate

liver

tibialis anterior
tibialis posterior
gastroc, soleus

gonadal
genital duct
external genital

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4
Q

Gonadal deveopment- primordial germ cells near yolk sac migrate towards G__
under influence of __ on Y chromo, male gonads produce testosterone/MIF

Ductal- MIF causes __ ducts to regress, w development of wolffian ducts
in females, lack of T/MIF leads to __ ducts regressing, while paramesonephric ducts proliferate

genitl tubercle forms __ in males, __ in femles
urogenital folds form ventral aspect of __ and labia minora in females
genital swellings become __ in males, __ in females

urogenital sinus forms B/U/P/B in males
B, U, lower vagina and Bartholin glands in females

A

genital ridge
SRY

paramesonephric
mesonephric

glans penis, glans clitoris
male penis
scrotum, labia majora

bladder, urethra, prostate, bulbourethral

bladder, urethra

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5
Q

Thiazide diuretics dec __ sec and inc insulin resistance

In tubular fluid/plasma ultrafiltrate graph, downward slope indicates __
upward slope indicates secretion/non__

top line is __/__/__
inulin is not _ in renal tubules, while some creatinine is, and most __ is secreted

Urea is line __ as it is poorly reabsorbed in PT and free filtered from GC

line 4 is __ as it is reabsorbed in PT

Line 5 is avidly reabsorbed G/A

A

insulin

reabsorption
reabsorbed

PAH, Creatinine, Inulin
secreted,
PAH

2

bicarb

glucose, amino acids

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6
Q

ovarian mass w small, cuboidal cells in sheets/follicles/rosettes is (call exner body) __ tumor
have pink center w __ nuclei
plump w __ to give it a yellow gross color
unilateral and large, secrete __ leading to endometrial hyperplasia

enlargement of __ can compress the esophagus and cause dysphagia
can view __ aorta posterior on TEE
Ascending aorta lies __ to R PA
Aortic arch travels above RPA and left __

left pulm artery found superior to left __
SVC formed by union of R/L __ veins

aortic arch vessels
B, C, S

A

granulosa/theca cell
coffee bean
lipids
estrogen/inhibin

LA

descending thoracic
posterior
bronchus

main bronchus
brachiocephalic

brachiocephalic, left common carotid, left subclavian

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7
Q

RBC have __ mutase enzyme, which converts 13BPG to 23BPG
this yields no __, but allows for O2 delivery to tissues

Tuberous sclerosis due to mutation in gene coded proteins H__ TSC1/2

__ indicates nephropathy in DM pt

C/L are nonselective A/B blockers

A wave is atrial \_\_
C wave is bulging of \_\_
X wave is atrial \_\_
V wave is inflow of \_\_
Y wave is passive filling of \_\_

Rapid y descent indicates __
origin is R, cardiac surgery or __

prominent a wave indicates __

A

bisphosphoglycerate
ATP

hamartin

microalbuminuria

carvedilol, labetalol

contraction
TC valve
relaxation
venous blood
ventricle

constrictive pericarditis
radiation, Tb

Hypertrophic cardiomyopathy

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8
Q

to dx HIV, use __ for screening
__ blot to confirm

use __ blot to look for restriction site mutations, as DNA fragment length is altered

M__ is like S/N blot
sequence is labeled w __ tag, w degree of fluorescence corresponding to mRNA expressed

myosin light chain kinase adds Phos to myosin __ in smooth muscle

Myosin ADP-phos complex binds __
ADP-phos is then __ after this crossbridge forms
contraction occurs, and new __ displaces myosin from actin

__ is first gen H1 blocker, also blocks 5HT1/5HT2
used for __ overdose

A

ELISA
western

Southern

microarray
fluorescent

light chain

actin
released
ATP

cyproheptadine

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9
Q

A__ is 2nd gen antipsychotic

Plasma cells in MM susceptible to effects of Proteosome inhibs like B__
inhibition leads to excess p__ proteins, inducing apoptosis of plasma cells

Waldenstrom Macroglobulinemia has __ spike
Hyper__ sx and no crab findings

MGUS is __ w no crab findings
spike due to inc __

intracellular proteins tagged for degredation via U__
broken down by __
this allows for presentation by __

A

aripipazole

bozetomib
proapoptotic

IgM
viscosity

asx
plasma cells

ubqiuitin ligase
proteosomes

MHC Class 1

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10
Q

think __ w gastrin levels that inc after secretin admin due to abnormal AC activation
causes P__ cell hyperplasia w PU formation and diarrhea

Secretin released by s cells of __
Somatostain released by __ cells of panc/GI

Beta endorphin is endogenous opioid derived from __

Type 1 collagen is predominant form in __
also in T, S, S, L

CDK4/6 w cyclin __/__ phosphorylate Rb to release E2F for trxn

hallmark of SLE is formation of ___ activating complement w depleted levels

A

gastrinoma
parietal

duodenum
D

POMC

osteoid
teeth, skin, sclera, ligaments

D/E

Auotantibodies

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