vonWillebrand disease

Question 1

What is it caused by

Answer 1

a defect or deficiency of vWF

Question 2

How many types are there and describe them

Answer 2

3 types
type 1- 75% of cases and is mild
Type 2- 20 % of cases and has moderate bleeding
Type 3- extremely low levels of vWF, cause major problems

Question 3

What type of disorder is it conssidered

Answer 3

bleeding disorder

Question 4

Von Willebrand give someone a compound defect of

Answer 4

platelet function and the coagulation pathway

Question 5

What are some manifestations

Answer 5

spontaneous bleeding of the nose, mouth, and gastro tract
excessive menstrual flow
prolonged bleeding with normal platelet count

Question 6

How is it diagnosed

Answer 6

when surgery or dental extraction result in prolonged bleeding

Question 7

In sever cases what can happen

Answer 7

life threatening gastrointestinal bleeding and joint hemorrhage similar to hemophilia

Question 8

What is the usual treatment

Answer 8

avoidance of aspirin 
Desmopressin acetate (DDAVP) for surgery 
factor VIII containing vWF for bleeding