Osteogenesis Imperfecta Flashcards
1
Q
What is Osteogenesis Imperfecta?
A
hereditary disorder caused by deficiencies in the synthesis of type I collagen
2
Q
How is this disorder characterized?
A
thin and poorly developed bones, prone to multiple fractures
3
Q
What are the mani of OI?
A
W eak bones L oose joints P oor quality of teeth S hort stature, below average height B lue sclera which is a blue tint to the whites of the eyes H earing loss
4
Q
Why do they get hearing loss?
A
otosclerosis of the tiny bones n the middle ear
5
Q
The most serious defects occur when the disorder is inherited as a recessive trait (type 2), what are the characteristics?
A
multiple intrauterine franctures
bowing/shortening of the extremities
6
Q
What is the treatment?
A
No definitive treatment
bone density and strength meds
Alignment and surgery
