Polycystic Kidney disease Flashcards
What is the cause of Dominant Polcystic kidney disease
a mutation of the genes in chromosome 16 & 4 that code for the membrane protein polycystin 1 or 2 leading to the proteins loss of function
What happens in PKD
renal cysts form in the kidneys’ nephron loops and collecting ducts
When do symptoms appear
30-50 years old
some people begin to experience symptoms in childhood
What are some symptoms of PKD
high blood pressure, back or side pain, and a swollen abdomen.
recurrent UTIs for dominant
chronic UTI’s for recessive
Chronic pain due to UTI’s, stones, and malignancies
hematuria
brian aneuryms
diverticulosis
What are some treatments
medication to control blood pressure, pain relievers, and cyst removal. A kidney transplant might be needed.
How is it diagnosed
blood test
urina analysis
Ultrasound on the abdomen to check for cysts
How do multiple cysts on kidneys effect function
ability to filter, make urine, over-activation of RAAS because the kidney isn’t being perfused with enough blood
What is the cause of Recessive Polcystic kidney disease
defect on chromosome 6
What is the primary defect of recessive PKD
dilated collecting ducts
When is recessive usually diagnosed
infant or early childhood
Is the prognosis of recessive PKD usually good or bad
bad, 1:1000 survive
How common is AD PKD
most common inheirited kidney disease
Which genetic form of AD PKD progresses faster
PKD 1
Where can you get cysts besides the kidney
liver, pancreas, and ovaries
