Blood brain and cerebrospinal fluid barrier Flashcards

1
Q

What substances pass enter the brain with ease

A

water
oxygne
carbon dioxide

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2
Q

What are most brain capillaries surrounded by

A

a basement membrane

feet end of astrocytes

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3
Q

What type of molecules can easily pass through the blood brain barrier

A

highly lipid soluble molecules

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4
Q

What are some example of lipid soluble molecules that pass through the BBB

A

alcohol
nicotine
heroin

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5
Q

What is different about the BBB in infants

A

the BBB is immature so it is much more permeable

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6
Q

What three things in brain capillaries contributes to its decreased permeability

A

the tight junctions between cells
the continuous basement membrane
astrocytes

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7
Q

What are some things that can increase permeability in the brain capillaries

A

trauma

infection

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8
Q

What form the cerebrospinal fluid brain barrier

A

the ependymal cells of the choroid plexus

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9
Q

What are some molecules that dont get past the cerebrospinal BB

A

medicaitions
large peptides
proteins

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10
Q

What are some molecules that are actively transported into the CSF

A

proteins
sodium
Vit C and B6
folate

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