Blood brain and cerebrospinal fluid barrier Flashcards
What substances pass enter the brain with ease
water
oxygne
carbon dioxide
What are most brain capillaries surrounded by
a basement membrane
feet end of astrocytes
What type of molecules can easily pass through the blood brain barrier
highly lipid soluble molecules
What are some example of lipid soluble molecules that pass through the BBB
alcohol
nicotine
heroin
What is different about the BBB in infants
the BBB is immature so it is much more permeable
What three things in brain capillaries contributes to its decreased permeability
the tight junctions between cells
the continuous basement membrane
astrocytes
What are some things that can increase permeability in the brain capillaries
trauma
infection
What form the cerebrospinal fluid brain barrier
the ependymal cells of the choroid plexus
What are some molecules that dont get past the cerebrospinal BB
medicaitions
large peptides
proteins
What are some molecules that are actively transported into the CSF
proteins
sodium
Vit C and B6
folate