Cytokines and Chemokines Flashcards
1
Q
What is the major source of IL-1 and TNF-a
A
macrophages
2
Q
How do they effect endothelial cells
A
causes them to express adhesion molecules
release cytokines,chemokines, and oxygen radicals
3
Q
How do they effect neutrophils
A
they cause priming and aggregation
4
Q
They are involved in what symptoms of acute inflammtion
A
fever, anorexia, hypotension, increased heart rate, release of corticosteroid hormones
5
Q
The outcome of acute inflammation generally results in what three processes
A
resolution
progression into chronic inflammmation
substantial scarring and fibrosis
