Klinefelter Syndrome

Question 1

What is the cause of Klinefelters syndrome

Answer 1

An extra X chromosome on the XY of males due to nondisjunction during meiotic division in one of the parents

Question 2

Klinefelters syndrome is characterized by

Answer 2

enlarged breast
sparse facial and body hair
small testes
inability to produce sperm

Question 3

Is the male phenotype still retained if their are multiple extra X chromosomes

Answer 3

yes

Question 4

Is the condition easy to detect at birth

Answer 4

no

Question 5

Is Klinefelters disease common

Answer 5

it is the most common disease of sex chromosomes

Question 6

What hormone is less produced

Answer 6

testosterone

Question 7

What are some complication that can happen later in life due to lower levels of testosterone

Answer 7

abnormal body proportions, longer legs than torso
abnormal fat distribution
retainment of feminine voice pitch
reading and writing learning disabillities
infertility due to low sperm count

Question 8

What type of hormone might increase in someone with Klinefelters

Answer 8

hypothalamic gonadotrophic hormones

Question 9

How is it usually treated

Answer 9

androgen and testosterone tharapy

Question 10

Due to breast inlargements what is recommended to males with this disease

Answer 10

self-examinations because of their increased risk of breast cancer

Question 11

What do males with klinefelters have that causes the low testosterone and high hypo gonad hormones

Answer 11

congenital hypogonadism

Question 12

How common is Klines

Answer 12

1 in 500-1000

Question 13

How is it diagnosed

Answer 13

blood and urine samples for abnormal levels of hormones

chromosome analysis