Sickle Cell Anemia Flashcards
Is it recessive or dominant
recessive
Sickle cell anemia is caused by
a mutation in the gene that codes for beta hemoglobin
What is sickle cell anemia
your RBCs are in the shape of a sickle or cresent moon
Why the is sickle shape problematic
the RBCs cant carry enough oxygen to the body and they can get stuck in small blood vessels
What are some symptoms of sickle cell anemia
D Delayed growth due to malnutrition
E Episodes of pain in the abdomen, chest, joints, and
bones (Acute Chest syndrome for example)
F Frequent infections- damage to spleen leaves you
more susceptible
S Swelling of the hand and feet because of vascular
occlusion
A Anemia- less oxygen supply because the sickle cells
break quickly
V Vision problems leading to blindness
After the mutation of beta hemoglobin happens, what is the sickle shaped hemoglobin called
HbS
What is another complication that can arise with Sickle Cell anemia
stroke because of occlusion in the cerebral vasculature
The mutation of the beta hemoglobin gene causes what to happen in the hemoglobin
the glutamic acid in the two beta globin chains of the hemoglobin are replaced with valine, causing a them to be misshaped
what are some treatments
medications to reduce pain and complications, and blood transfusions, bone marrow transplant.
