Syndrome of inappropriate ADH (SIADH) Flashcards
What happens to someone with this syndrome
excessive ADH secretion in the absence of hypovolemia or hyperosmolality b
Can it be acute or chronic
both
Why does it happen
the negative feedback system of the hypothalamus isnt working
What are some causes that relate more to acute SIADH
surgery
stress
temperature changes
and possibly drugs that increase ADH production or act on the renal tubules
What are some causes that relate to chronic
Tumors of the brain and lungs
CNS disorders
advanced TB
HIV
What are the mani’s
dilutional hyponatremia
decreased urine output despite adequate or increased intake
urine osmolarity is high while serum osmo is low
decreased levels of serum sodium, hematocrit, and BUN levels
What is the severity of the symptoms dependent on
degree of sodium depletion and water intoxication
What are the treatments
in mild case- fluid restriction
if fluid restriction isn’t enought: diuretics and lithium
sever cases of water intox: patient gets a hypertonic sodium chloride solution of 3%
Biggest difference between SIADH and DI
SIADH is low vs DI is high levels of urine