Rhabdomyolysis Flashcards
What causes Rhabdo
Crush injuries (MVC, WRI) Viral infections Cocaine, heroin, amphetamines Long distance runners and military recruits Electric shock Malignant hyperthermia Status epilepticus
What is the disease interchangable with
myoglobinuria
What is the pathology of Rhabdo
Rapid breakdown of muscle that causes the release of intracellular contents into extracellular space and bloodstream
What are the manifestations
Muscle pain, muscle weakness, dark urine
increased levels of myoglobin, creatine kinase, K+
What gives the urine its coca cola appearance
myoglobin in the urine
because the excessive amount of protein hits the kidney it causes kidney damage resulting in
increased potassium
decreased calcium
metabolic acidosis
What is an example of a scenario where large amounts of intracellular components from the damaged tissue can cause kidney damage
relieving a crushing injury
Whats the treatment
high fluid intake
Why is high fluid intake the treatment
because the increased fluid helps push the excessive amounts of protein out of the body so they don’t clog up the kidney and form casts
