Lecture 1: Body Fluid Compartments and Transport Across Cell Membranes Flashcards
How much total body water does a 20kg dog have?
20 kg x 0.6 L =12 kg or 12 L
what are the two major fluid compartments
ICF - intercellular fluid
ECF - extracellular fluid
what is the percent volume of ICF
40%
What is the percent volume of ECF
20%
what are the two compartments of the ECF
Plasma and interstitial fluid
what is the percent volume of plasma in the ECF
4%
what is the percent volume of intersitital fluid in the ECF
16%
What is the ECF volume of a 105kg pig?
105kg x 0.2 = 21 L or 21,000 mL
What is the average blood volume of an animal
70 mL/kg
What is the average total body water in animals
60%
define equivalent
amount of charged solutes
CaCl2 = 4 equivalents
define Osmole
number of particles into which a solute dissociates in solution
What does pH express
H ion concentration
- H ion concentration in body fluids is relatively low, so express as a log term (pH)
- pH = -log10[H+]
what is the term for each body fluid compartment must have the same concentration of cations as anions
electroneutrality
What is the major cations of the ECF
Na+
what is the major anions of the ECF
Cl- and HCO3-
What is the major cations in the ICF
K+
What is the major anions in the ICF
organic phosphates and proteins
which cellular fluid compartment has low ionized Ca2+ and is more acidic
ICF
- Bound: bound to other substances and not free to interact
Free : About to interact with other substances
When the ICF and ECF have the same osmolarity it is said to be
electroneutral
what is the average osmolarity in the body
290-300 mOsm/L
What is the plasma volume of a 6kg cat?
240 mL
Cell membranes are/are not freely soluble to all solutes making it selectively permeable
are not
What two transport mechanisms directly use ATP
Na+ / K+ ATPase pump
- move sodium out of the cell and potassium into the cell
Ca2+ / ATPase pump
- Moves calcium out of the cell
Transporters for glucose, amino acids, Ca2+, H+ utilize __________ gradient, but dont directly use energy
Na+