Exam 3: Lecture 32 Flashcards
Calculate the RPF for a 20 kg dog with the following values:
V = 2.0ml/min
Pinulin = 2.0 mg/mL: Uinulin = 100 mg/mL
PPAH = 3.0mg/mL; UPAH = 450 mg/mL
RPF = (UPAH x V)/PPAH
RPF = 15mL/min/kg
T/F: Glomerular filtration does not require an input of energy.
True
Water, Na, Cl, HCO3, glucose, AA, urea, Ca, Mg, phosphate, lactate, and citrate are (reabsorbed/secreted) to/from tubular fluid.
Reabsorbed from
Organic acids, bases, and K are typically (reabsorbed/secreted) to/from tubular fluid.
secreted to
A greater filtered load than excretion rate will cause what?
Net reabsorption of substance
A lesser filtered load than excretion rate will cause what?
Net secretion of substance
Where does glucose reabsorption occur?
Proximal convoluted tubule
T/F: Glucose can freely transport all the time, there is no limit.
False - there is a limited number of glucose transporters, so there is a transport maximum
When plasma glucose is under 200mg/dL what happens to the filtered glucose?
It is reabsorbed
What is splay?
When glucose reabsorption is approaching saturation, glucose shows up in urine before Tmax is reached.
What is Glucosuria?
Excretion/spilling of glucose into urine
What are three disorders/diseases that can cause glucosuria?
- Uncontrolled diabetes
- Can happen in pregnancy
- Defects in Na+/glucose co-transporter
What disease can be acquired or congenital, and is associated with disorders in the proximal tubule causing issues with glucose transport?
Fanconi syndrome
What breed of dog is Fanconi syndrome autosomal recessive?
Basenji
In what species will high stress cause hyperglycemia?
Cats
