Week 5 - Osmolality Flashcards
What is osmolality?
-indicator of water balance (concentration)
What is the range for N Plasma Osmolality?
- 285-295 mOsm/kg
What does it mean if plasma osmolality is higher than >295?
water deficit - too little water or too much solute
What does it mean if plasma osmolality is less than 285?
Water excess - too little solute or too much water
Cells are affected by osmolality of fluids around them. What osmolality do isotonic fluids have? (2)
- equal osmolality
aka neutral concentration between ICF and ECF
What osmolality do hypertonic fluids have?
- have higher osmolality (shrinks cells)
What osmolality do hypotonic fluids have?
- have lower osmolality (swell cells)
Fluid shifts diagram*
Which area of the brain is responsible for regulation of water balance?
- hypothalamus-pituitary gland in brain
What is the mechanism in which the hypothalamus regulates water balance? (4)
- Hypothalamus osmoreceptors sense increased osmolality
- too many particles, not enough fluid - Thirst triggered (decreased in older adult)
- ADH released from pituitary gland
- in kidney, free water absorption (not Na) - ADH release can be triggered by increased plasma osmolality, stress, nausea, nicotine, and morphine
Why happens to osmolality if you are dehydrated?
- osmolality goes up and thirst is triggered
Must know RAAS, in perfusion unit
ok
What is aldosterone’s role in the kidneys?
- stimulates kidneys to reabsorb water and sodium
What is the role of ADH? (2)
- kidneys reabsorb more water, not Na+
- This dilutes our blood so the Na+ concentration drops
What occurs in the GI regulation of water? (2)
Intake: source of new water for the body
Output: Diarrhea and vomiting may lead to excessive water loss and electrolyte loss
In lecture, hypokalemia and decreased water