Week 10 - Anticholinergics + Other Drugs Flashcards
1
Q
What are anticholinergic drugs?
A
- improve the function by blocking parasympathetic nervous system in bronchi
2
Q
What are the 2 anticholinergic drugs discussed?
A
- Ipratropium
- Tiotropium
3
Q
What is the MOA of anticholinergics?
A
- Blocks muscarinic cholinergic receptors in the bronchi, preventing brochoconstriction
4
Q
What are the characteristics of Ipatropium? (4)
A
- Atrovent
- Short acting
- Onset of Action is within 30 seconds, duration of 6 hours
- Adverse effects include dry mouth and irritation to pharynx
5
Q
What are the characteristics of Tiotropium? (5)
A
- Spiriva
- long acting
- Onset of action is 30 min, duration of 24 hours
- for maintenance of bronchospasm associated with COPD
- adverse effects include dry mouth
6
Q
What are the 2 combination drugs?
A
- Glucocorticoid/Long-acting Beta 2 agonist (symbicort/advair)
- Beta 2 adrenergic agonist/anticholinergic (Combivent)
7
Q
What is Symbicort/Advair? (3)
A
- anti-inflammatory and bronchodilation
- pro is that it is convenient
- con is restrictinf dosage flexibility
8
Q
When would Symbicort/Advair be given/indicated?
A
When asthma has not been controlled w/ inhaled glucocorticoids
9
Q
How do beta 2 Adrenergic agonist/anticholinergics (combivent) work?
A
optimize bronchodilation
10
Q
What are the advantages of using an inhaler? (3)
A
- Therapeutic effects enhanced by delivering directly to site of action
- systemic effect minimized
- relief of acute attacks is rapid
11
Q
What are the four types of inhalation devices? (4)
A
- Metered Dose Inhalers (MDIs) - fine liquid sprays
- Respimats - Very fine mists
- Dry Powder Inhalers (DPIs) - fine powder
- Nebulizers - Converts drug solution to a mist
12
Q
Spacers Slide
A
13
Q
Why is it important to correctly administer MDIs and DPIs? (2)
A
- Using an MDI with a spacer is easier and improves inhalation of the drug
- DPI requires less manual dexterity and coordination
