Week 3: Pharmacokinetics - Excretion

Question 1

Where does excretion occur in the body? (2)

Answer 1

• kidney
• also lungs or biliary excretion

Question 2

Which drugs can cross the membrane?

Answer 2

nonionized, lip soluble drugs

Question 3

What are the 3 steps in excretion?

Answer 3

1. Glomerular filtration
2. Passive reabsorption
3. active transport

Question 4

What occurs in glomerular filtration? (2)

Answer 4

• filtration moves drugs from blood to urine
• protein bound drugs are not filtered

Question 5

What occurs in passive reabsorption? (2)

Answer 5

• lipid soluble drugs move back into the blood
• polar and ionized drugs remain in the urine

Question 6

What occurs in active transport?

Answer 6

• tubular “pumps” for organic acids and bases move drugs from blood to urine