TIOTROPIUM Flashcards
1
Q
Drug class
A
anticholinergic
2
Q
How does it work? (2)
A
- bind to muscarinic receptor
- they act as a competitive inhibitor of acetylcholine
3
Q
What does stimulation of the muscarinic receptors bring about?
A
- wide range of parasympathetic/ ‘rest and digest’ effects
4
Q
What does blocking the muscarinic receptors bring about? (6)
A
- increase heart rate
- increased heart conduction
- reduced smooth muscle tone in resp tract
- reduced secretions from glands in reap and GI tracts
eyes
- cause relaxation of the pupillary constrictor, cilary muscles
- cause pupillary dilation
- prevent accommodation
5
Q
Indications (2)
A
- COPD
- Asthma
6
Q
Contra-indications (2)
A
- Angle closure glaucoma
- dangerous rise in intro-occular pressure
7
Q
Side effects
A
dry mouth
8
Q
Interactions
A
none
9
Q
Elimination (2)
A
- IV –> urine
- inhalation –> faeces
