ISOSORBIDE MONONITRATE Flashcards
1
Q
Drug class
A
Nitrates
2
Q
How does it work? (5)
A
- nitrates are converted into NO
- NO increases cyclic guanosine monophosphate (cGMP)
- this reduces intra-cellular Ca2+ in vascular smooth muscle cells
- this causes venous and arterial vasodilation
- this reduces cardiac preload and left ventricular filling
3
Q
Indications
A
- prophylaxis of angina
4
Q
Contra-indications (2)
A
- severe aortic stenosis
2. hypotension
5
Q
Side effects (3)
A
- face and head
- flushing
- headache
- light headedness
- hypotension
- increased tolerance
6
Q
Interactions and what does it do?
A
- phosphodiesterase inhibitors
- enhance or prolong hypotensive effects
7
Q
Elimination (2)
A
- urine
2. bile
