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YEAR 3 DRUGS > DICLOFENAC > Flashcards

DICLOFENAC Flashcards

1
Q

Drug class

A

NSAIDS

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2
Q

how does it work? (2)

A
  1. block COX enzymes

2. prevents the production of prostaglandins and distribution of them around the body

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3
Q

Indications

A
  1. pain
  • periods
  • inflammatory
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4
Q

Contra-indications (4)

A
  1. hypersensitivity
  2. GI
  • peptic ulcer
  • bleeding
  1. heart
  • CVD
  • heart failure
  1. kidneys
    - severe renal impairment
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5
Q

Side effects (5)

A
  1. GI
    - toxicity
  2. renal
    - impairment
  3. heart
    - CVS events
  4. hypersensitivity
  5. fluid retention
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6
Q

Interactions (9) a lot!!!!!

A

INCREASE GI ULCERATION

  1. aspirin
  2. corticosteroids

GI BLEEDING

  1. anticoagulants
  2. SSRIs

RENAL IMPAIRMENT

  1. ACE inhibitors
  2. diuretics

RISK OF BLEEDING

  1. warfarin

REDUCED THERAPEUTIC EFFECTS

  1. anti-hypertensives
  2. diuretics
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7
Q

Elimination (2)

A
  1. urine mainly

2. some in bile

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YEAR 3 DRUGS (65 decks)

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