RIVOROXABAN Flashcards

1
Q

Drug class

A

novel anticoagulant

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2
Q

How does it work? (3)

A
  • binds to factor Xa
  • prevents the formation of thrombin
  • hence prevents the formation of blood clots
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3
Q

Indications (3)

A
  1. vessels
  • dvt
  • pe
  1. surgery
  2. heart
    - AF
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4
Q

Contra-indications (2)

A
  1. active bleeding

2. severe hypersensitivity reaction

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5
Q

Side effects (there are a lot!) (8)

A
  1. muscles and joints
    - back pain
  2. GI
  • black/red stools
  • dark/red urine
  • bowel or bladder dysfunction
  • vomitting - blood or coffee ground material
  1. gums
    - bleeding
  2. head
  • headache
  • dizziness
  1. pins and needles
  2. leg weakness
  3. prolonged bleeding from cuts
  4. lungs
    - coughing up blood
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6
Q

Interactions (4)

A
  1. cytochrome P450 inhibitors
  2. cytochrome P450 inducers
  3. NSAIDs
  4. Aspirin
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7
Q

Elimination (2)

A

50: 50
1. hepatobiliary
2. renally

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