MADOPAR/SINEMET

Question 1

Drug class

Answer 1

L dopa/ peripheral decarboxylase inhibitors

Question 2

How does it work?

Answer 2

1. increases dopaminergic stimulation to the striatum

2. it is a precursor of dopamine

Question 3

Why cannot you give dopamine itself?

Answer 3

it does not cross the blood brain barrier

Question 4

Indications

Answer 4

1. Parkinson’s disease

Question 5

Contra-indications (3)

Answer 5

1. elderly
2. existing cognitive or psychiatric disease

RISK OF CONFUSION AND HALLUCINATIONS

3. CVD
   - risk of hypotension

Question 6

Side effects (5)

Answer 6

1. nausea
2. drowsiness
3. hallucinations
4. hypotension
5. wearing off effect

• excessive and involuntary movements
• on/off effect

Question 7

Interactions (2)

Answer 7

1. antipsychotics
2. metoclopramide

effects on dopamine receptors are contradictory

Question 8

Elimination (2)

Answer 8

1. urine (64%)

2. faeces (24%)