DOXYCYCLINE Flashcards

1
Q

Drug class

A

tetracycline

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2
Q

How does it work?

A
  • inhibits bacterial protein synthesis

- bactriostatic

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3
Q

Is doxycycline broad or narrow spectrum?

A

broad

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4
Q

Indications (4)

A
  1. skin
    - acne vulgaris
  2. Lungs
  • LRTI
  • infective exacerbations of COPD
  1. Pelvis
    - chlamydia
  2. Infectious
  • typhoid
  • anthrax
  • lyme disease
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5
Q

Contra-indications (3)

A
  1. pregnancy and breast feeding
  2. kids under 12 years old
  3. renal impairment
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6
Q

Side effects (4)

A
  1. GI
  • diarrhoea
  • vomitting
  • nausea
  1. Hypersensitivity
  2. Oesophageal
  • irritation
  • ulceration
  • dysphagia
  1. Head
  • intra-cranial hypertension
  • headache
  • visual disturbance
  • photosensitivity
  • hypoplasia of tooth enamel
  • discolouration
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7
Q

Interactions (3)

A
  1. Divalent cations
    - binds to them
  2. calcium, antacids and iron
  • will prevent antibiotic absorption
  • not to be given with in 2 hours of them
  1. warfarin
    - enhance anti-coagulant effects
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8
Q

Elimination (2)

A
  1. bile

2. urine

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