RANITIDINE Flashcards
1
Q
drug class
A
H2 receptor antagonist
2
Q
how does it work? (6)
A
- reduces gastric acid secretion
- the proton pump is regulated by histamine
- histamine is released by local paracrine cells
- histamine then binds to H2 receptors on the gastric parietal cell
- this activates the proton pump
- Ranitdine binds to H2 receptor preventing this action
3
Q
How does the proton pump work and what does it do? (3)
A
- it produces gastric acid
- by secreting H+ into the stomach lumen
- this is in exchange for drawing K+ into the cell
4
Q
Which messenger system activates the proton pump?
A
second messenger sysetm
5
Q
Do H2 receptor antagonists completely suppress gastric acid production?
A
no
6
Q
Do PPIs completely suppress the gastric acid production?
A
yes
7
Q
Indications (3)
A
- peptic ulcer disease
- GORD
- dyspepsia
8
Q
Contra-indications (2)
A
- dose should be reduced in renal patients
- disguise symptoms of gastric cancer
9
Q
Side effects (3)
A
- bowel disturbance
- headache
- dizziness
10
Q
Interactions
A
none
11
Q
Elimination
A
kidneys
