BENDROFLUMETHIAZIDE

Question 1

Drug class

Answer 1

1. thiazide diuretics

Question 2

How do they work? (4)

Answer 2

1. inhibit the Na/K/Cl co-transporter in the distal convoluted tubule of the nephron
2. this prevents the reabsorption of sodium
3. it is hence osmotically associated with water
4. consequently having a diuretic effect

Question 3

Indications (2)

Answer 3

1. hypertension - vasodilation

2. heart failure

Question 4

Contra-indications (3)

Answer 4

1. gout
2. hypokaelemia
3. hyponaetremia

Question 5

Side effects (3)

Answer 5

1. hypokaelemia patients
   - cardiac arrhythmias
2. hyponaetremic patients
   - cardiac arrhythmias
3. impotence in men

Question 6

Interactions (2)

Answer 6

1. NSAIDS
   - effectiveness reduced
2. Loop diuretics
   - as they have a low serum potassium concentrations

REQUIRE CLOSE MONITORING

Question 7

Eliminations

Answer 7

kidneys - rapidly