CEPHRADINE Flashcards

1
Q

Drug class

A

cephalosporin

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2
Q

How does it work? (4)

A
  • Inhibit enzymes involved in cross-linking peptidoglycans in bacterial cell walls
  • this weakens cell walls
  • and prevents them from holding an osmotic gradient
  • this results in bacterial cell swelling, lysis and death
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3
Q

What is the effects of cephradine due to?

A

beta lactam ring

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4
Q

Is it broad or narrow spectrum?

A

broad

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5
Q

What bacteria does it tend to work against?

A

gram negative bacteria

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6
Q

Indications for oral (2)

A
  • resp

- UTIs

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7
Q

Indications for iV (2)

A
  1. severe infections

2. antibiotic resistance organisms

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8
Q

Contra-indications (4)

A
  1. those at risk of c.diff
  • elderly
  • inpatients
  1. allergy
  • penicillin
  • cephalosporin
  • carbapenems
  1. epilepsy
  2. renal impairment
    - dose reduction
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9
Q

Side effects (2)

A
  1. GI upset
  • nausea
  • vomitting
  • Anitbiotic colitis e.g. c.diff
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10
Q

Interactions (2)

A
  1. warfarin
  • enhance anti-coagulation effect
  • by killing the normal gut flora that synthesises vit K
  1. aminoglycosides
    - increased nephrotoxicity
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11
Q

Eliminations

A

urine

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