MESALAZINE Flashcards
1
Q
Drug class
A
aminosalicyates
2
Q
How does it work? (2)
A
- it releases 5-aminosalicyclic acid (5-ASA)
- it has anti-inflammatory and immunosuppressive effects
3
Q
Where in the body does mesalazine act?
A
gut
4
Q
Indications
A
mild to mod ulcerative colitis
5
Q
Contra-indications
A
- patients with aspirin hypersensitivity
6
Q
Side effects (2, 3)
A
- GI upset –> nausea and dyspepsia
- headache
RARE
- blood abnormalities e.g. thrombocytopenia
- renal impairments
- hypersensitivity reaction - fever, rash and liver abnormalities
7
Q
Interactions (3)
A
- proton pump inhibitors
- coating is broken down prematurely
- 5-ASA released earlier on
8
Q
Why is the coating of mesalazine resistant to gastric breakdown?
A
- in order to realises 5-ASA further down the gut
9
Q
Elimination
A
urine and faeces
