NITROFURANTOIN Flashcards
1
Q
Drug class
A
Nitrofurantoin
2
Q
How does it work? (2)
A
- active metabolite damages bacterial dna
- causes cell death - bactericidal
3
Q
What bacteria does it work against?
A
- gram negative - e.coli
2. gram positive - staph saprophyticus
4
Q
Indications
A
- uncomplicated lower urinary tract infection
5
Q
Contra-indications (4)
A
- pregnant
- babies
- renal impairment
- long term UTIs
6
Q
Side effects (4)
A
- GI upset
- nausea
- diarrhoea
- hypersensitivity
- dark/brown urine
LESS COMMON
- chronic pulmonary reactions
7
Q
Interactions
A
none
8
Q
Elimination (2)
A
- bile
2. urine
