SIMVASTATIN Flashcards
1
Q
Drug class
A
statin
2
Q
How does it work? (2)
A
- reduces cholesterol levels (LDLs)
2. by inhibiting HGM coA reductase enzyme which is involved in cholesterol synthesis
3
Q
Indications (2)
A
- CVD
2. hyperlipidaemia
4
Q
Contra-indications (3)
A
- pregnancy and breast feeding
- hepatic impairment
- renal impairment
5
Q
Side effects (4)
A
- head
- headache - GI upset
- Muscles
- rhabdomyolysis
- muscle aches
- liver
- rise in liver enzymes
6
Q
Interactions
A
cytochrome P450 inhibitors
e. g. amiodarone
- reduces effectiveness
- Grapefruit
7
Q
Elimination
A
- renal
