SENNA Flashcards
1
Q
what is the drug class?
A
laxative
2
Q
how does it work? (4)
A
- is a stimulant
- it increases water and electrolyte secretion from colonic mucosa
- this increases colonic content
- and stimulates peristalsis
3
Q
how does senna stimulate peristalsis? (4)
A
- senna is metabolised by bacteria in the intestine
- this produces metabolites
- these metabolites have a direct action on the enteric nervous system
- this stimulates peristalsis
4
Q
Indications
A
constipation
5
Q
Contra-indications (3)
A
- intestinal obstruction
- haemorrohoids
- anal fissures
6
Q
Side effects (3)
A
- abdo pain
- diarrhoea
- melanosis coli
7
Q
What is melanosis coli?
A
reversible pigmentation of the intestinal wall
8
Q
interactions
A
none
9
Q
elimination
A
faeces or urine
