AMITRYPTILINE Flashcards

1
Q

Drug class

A

Tricyclic antidepressant

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2
Q

How does it work? (4)

A
  1. inhibit neuronal reuptake of serotonin and nordrenaline from the synaptic cleft
  2. this increases their availability for neurotransmission
  3. consequently improving mood in depression
  4. and improving neuropathic pain
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3
Q

Indications (2)

A
  1. moderate to severe depression

2. neuropathic pain

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4
Q

Contra-indications (4)

A
  1. Elderly
  2. CVD
  3. Head
  • epilepsy
  • raised intra-occular pressure
  1. GI/ Urological
  • prostate hypertrophy
  • constipation
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5
Q

Side effects (4)

A
  1. block anti-muscarinic receptors
  • dry mouth
  • constipation
  • urinary retention
  • blurred vision
  1. Blockage of H1 and alpha 1 receptors
  • sedation
  • hypotension
  1. ECG changes
    - prolongation of QT and QRS
  2. Brain
  • convulsions
  • hallucinations
  • mania
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6
Q

What happens in overdose? (4)

A
  1. BP
    - severe hypotension
  2. heart
    - arrhythmias
  3. resp
    - reap failure
  4. brain
  • convulsions
  • coma
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7
Q

What happens in sudden withdrawal of amitryptiline? (4)

A
  1. GI upset
  2. neurological
  3. influenza like symptoms
  4. sleep disturbance
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8
Q

Interactions and why?

A
  1. monoamine oxidase inhibitors
  • both increase serotonin and NA levels at synapse
  • precipitates hypertension and hyperthermia or serotonin syndrome
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9
Q

Eliminations (2)

A
  1. faeces

2. bile

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