ASPIRIN

Question 1

Drug class

Answer 1

anti-platelet

Question 2

How does it work? (4)

Answer 2

1. irreversibly inhibits cyclooxygenase (COX)
2. this reduces the production of thromboxane from arachidonic acid
3. this reduces platelet aggregation
4. this reduces the risk of arterial occlusion

Question 3

Indications (4)

Answer 3

1. heart

• ACS
• CVD
• atrial fibrilation

2. fever
3. pain
   - mild to moderate
4. arterial disease
   - peripheral arterial disease

Question 4

Contra-indications (5)

Answer 4

1. Under 16 years
   - reyes syndrome
2. hypersensitivity
3. pregnancy
   - third trimester
4. joints
   - gout
5. stomach
   - peptic ulceration

Question 5

Side effects (3)

Answer 5

1. GI

• irritation
• haemorrhage
• ulceration

2. lungs
   - bronchospasm - hypersensitivity reaction
3. ears
   - tinnitus

Question 6

Interactions

Answer 6

given with caution with other anti-platelets and anticoagulants in ACS

Question 7

Elimination

Answer 7

• urine