GENTAMICIN Flashcards
1
Q
Drug class
A
aminoglycoside
2
Q
What type of bacteria does it work on?
A
gram negative aerobes e.g. pseudomonas aeruginosa
3
Q
How does it work? (3)
A
- binds irreversibly to bacterial ribosomes
- and inhibits protein synthesis
- kills bacteria -bacteriacidal
4
Q
How does gentamicin enter the gram negative aerobic bacteria?
A
via the oxygen dependent transport system
5
Q
Inidcations (3)
A
- sepsis
- severe
- bilary
- intra-abdominal
- kidneys
- pyelonephritis
- complicated UTI
- heart
- endocarditis
6
Q
Contra-indications (2)
A
- RENAL, COCHLEAR AND VESTIBULAR DAMAGE
- elderly
- neonates
- renal impaired
- IMPAIRS NEUROMUSCULAR TRANSMISSION
- Myasthenia gravis
7
Q
Side effects (2)
A
- ototoxicity
2. nephrotoxicity
8
Q
Interactions (2, 4)
A
- otoxicity
- furosemide
- vancomycin
- nephrotoxicity
- ciclosporin
- platinum chemotherapy
- cephalosporins
- vancomycin
9
Q
Elimination
A
urine
