CLOPIDOGREL Flashcards
1
Q
Drug class
A
anti-platelet
2
Q
How does it work? (2)
A
- binds irreversibly to adenosine bisphosphate receptors (ADP) (P2Y-12 subtype) - on the surface of platelets
- reduces formation of thrombus
3
Q
Indications (3)
A
- heart
- ACS
- CVD
- AF
- coronary artery stents
- brain
- cereberovascular disease - peripheral artery disease
4
Q
Contra-indications (4)
A
- severe active bleeding
- elective surgery
- renal impairment
- hepatic impairment
5
Q
Side effects (3)
A
- bleeding
- GI upset
- dyspepsia
- abdo pain
- diarrhoea
RARE
- thrombocytopenia
6
Q
Interactions (3)
A
- cytochrome P450 inhibitors
- metabolised by cytochrome P450 - omeprazole
- inhibits action - co-prescription with other anti-platelets and anti-coagulants
- increases risk of bleeding
7
Q
Elimination (2)
A
- renal
2. faecal