Test 93 Flashcards
Trousseau’s syndrome
migratory superficial thrombophlebitis–indication of a visceral cancer!!
several episodes of thrombophlebitis in various sites in both arms and legds
visceral cancer!!
hypercoagulatbility is a common paraneoplastic sydnrome commonly seen with adenocarcinomas of hte pancreas, colon and lung
survives inside MPHAGES
dauses a disseminated mycosis in IMmunoCOMP pts
SYSTEMIC sxs
painful oral ulcers
lymphadenopathy
hepatosplenogmegaly
Histoplasma capsulatum
**may also see hilar adenopathy
Aspergillus fumigatus
MONOmorphic fungi w/ ONLY a mold form
seen in tissue w/ ACUTE ANGLE V shaped branidng
Most frequent opportunistic pathogen
extracellular
forms ovoid yeast cells w/ pseudohyphae
CAndida
causes meningoencephalitis, pulmonary crtptoccocis in those w/ HIV
has a LARGE polysaccharide capsule (INDIA INK YO)
Cryptococus neoformas
can cause a disseminiated mycosis in immunocomp pts
large thicked walled spherules w/ endosspores
coccioides immits
counteract PNS stimulation of vagus causing bronchoconstriction in lungs
tiotroprium
ipratropium
ABrupt onset of gross hematuria in a pt w/ sickle cell disease
dark rust colored or bloody urine and acute coliky flank pain d/t acute utreteral obstruction from sloughed paipillae
COMMON SXS!!
Papillary necrosis!
(anything that decreases renal blood flow)
seen w/ sickle cell
DM
analgesic nephroapthy
severe obstrucive pyelonephritis
Muddy brown granular casts in hospitalized pt w/ oliguira
ischemic tubular necrosis
microangiopathic hemolytic anemia
thrombocytopenia
ARF
HUS
IL-1
IL-6
TNFa
mediate SYSTEMIC inflammatory response
stimulate hepatic secretion of acute phase proteins (fibrinogen)
High levels of circulating fibringoen increased ESR
heavy, red, boggy lobe
congestion
alveolar exudate contains mostly bacteria
red firm lobe liver like consistancey
red hepaization
alveolar exudate w/ RBC, neutrophils, fibirin
gray brown firm lobe
gray hepatatization
RBC disintegrate
alveolar exudste contains neutrophils and fibrin
most likely cause of fatigue and new onset cardiac murmur in young adult
bacterial endocarditis
complication of bacteria lendocarditis
acute diffuse proliferative glomerulonephritis secondary to circulating immune complexes
children
intussusception
hypersecretion of gastrin by a pancreatic tumor
ZE syndrome
increases gastric acid secretion> peptic ulcers
diarrhea is another common sx
chronic antral predominant gastritis
h. pylori infection
biphasic pattern of cellularity (highly cellular areas intermixed w/ myxoid regions of LOW cellularity)
Verocay bodies
S100 positivity
arise from peripheral nerves, nerve roots and cranial nerves
Schwannomas!!
often at cerebellopontine angle at CNVIII
anotehr important S100 + tumor
melanoma (schwannoma)
bizarre loking glial cells w/ mitotic figures
PSEUDOPALISADING necrosis
often in WHITE MATTER
crosses corpus collosum
glioblastoma
arise from cells of arachnoid
cells in whorls with psammoma bodies
meningiomas
optic glioma
commonly seen w/ NF1 (rosenthal fibers)
demyelinated plaques
MS
large intracytoplasmic vacuoles (spongiform)
CFJ D
HTN basal ganglia cerebellum thalamus pons intracerebral hemorrhage progressive neuro deficits
charcot bouchard
APKD, ED
circle of willis
2025 mm
SUB arachonoid hemorrhage
SUDDEN severe HA
no FOCAL neuro deficitis
sacccular (berry) anneurysms
deep intraparenchymal hemorrhage caused by hypertensive vasculopathy of small penetrating branches of cerebral arteries
charcot bouchard
ATN
can be assocaited w/ multiorgan FAILURE> most pts experience tubular re-epitheliazation adn REG’AIN normal renal fucntion
ortner syndrome
mitral stenosis > left atrial dilation sufficient to impinge on recurrent largyngeal nerve (HOARSENESS)
rising fever, bacteremia, brdaycardia>
abdominal pain rose spots>
hepatosplenomegaly, intestinal bleeding
typhoid fever
penetrates gut via phagocytosis by M cells
involuntary, rapid, irregular jerking movements involiving face arms and legs
syndham chorea
can occur MONTHS after GAS infection and is one of hte MAJOR clinical manifestations of ACute RF
**these pts have a high risk of valve disease
transmural inflammation w/ fibrinoid necrosis
PAN
associated w/ HBV!!!! in 10-30% of cases
granulomas w/ eosinophilic necrosis
churg strauss
impaired bone matrix formation
OI
bone matrix = hydroxy apatite crystals and type I colagen components
defect in mineralization of bone matrix
vit D def
endochondral ossification
long bones
intramembranous ossification
flat bones
rare but SEVERE complication of halothane exposure
massive HEPATIC NECROSIS
occurs d/t direct liver injury by halothane metabolites and formation of autoAbs against liver progetins
CENTRILOBULAR hepatic necrosis
microvesicular fatty chagne
REyes syndrome (kids 5-10 tx w/ salicylates)
macrovesicular fatty chagne
ETOH chronic
hepatic grannulomatosis
methyldopa
hydralazine
quinidine