Pharmacology Issues in Renal Failure Flashcards
What endogenous compounds induce dilation in the afferent arteriole?
NO PGE2 PGI2 Caffeine Dopamine
ACEi are category ________ in pregnancy.
D
How does efferent dilation affect GFR and RBF?
Decrease GFR
Increase RBF
What two things induce efferent arteriole constriction?
Norephinephrine
Angiotensin II
Modulate dosage of renally eliminated drugs for CKD stages ________.
3 - 5
One of the major complications of nephron loss is ____________.
increased PO4
What causes parathyroid hormone to be released?
Decreased serum calcium levels
What causes parathyroid hormone to be decreased?
Increased calcium
Increased vitamin D
Increased serum phosphate leads to increased FGF-23 which leads to ___________.
decreased serum calcium and increased parathyroid hormone–leading to bone disorders
Avoid potassium-sparing diuretics in those with _________.
stage 3-5 kidney disease
How does insulin lower potassium levels?
By inducing expression of NaK pumps
What are the side effects of kayexalate?
Constipation, bowel necrosis
Which ß-blocker has increased half-life in those with CKD?
Atenolol
Phosphate binders have ________ side effects.
GI
