Inotropic Drugs - Limitations in Heart Failure Flashcards

1
Q

Naprilysin ____________.

A

degrades BNP

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2
Q

Ivabradine blocks the _________, and thus __________.

A

I(funny) channels; decreases heart rate

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3
Q

Ivabradine is contraindicated in patients ______________.

A

who are pregnant, bradycardic, have liver impairment, or are taking CYP3A4-affecting drugs

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4
Q

Digoxin is cleared by the _________, so do not give it to patients with _________.

A

kidneys; renal failure

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5
Q

Digoxin levels are monitored are should be kept between ___________.

A

0.5 and 1.0 ng/ml

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6
Q

Digoxin has no benefit in those with ___________.

A

preserved ejection fraction

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7
Q

The population that is given digoxin is _________.

A

patients with refractory HF receiving ARBs/ACEI, ß-blockers, and diuretics; HFrEF patients who don’t respond to the standard triad of drugs

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8
Q

Patients receiving antiarrhythmics, antifungals, aminoglycosides, and calcium-channel blockers should have their digoxin __________.

A

reduced

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9
Q

The two main inotropic drugs are ____________.

A

dobutamine and milrinone

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10
Q

Milrinone is a _____________.

A

phosphodiesterase inhibitor

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11
Q

Dobutamine is a ___________.

A

ß1 agonist

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12
Q

Inotropic drugs (like dobutamine and milrinone) are given to those who are ________.

A

cold and wet

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13
Q

Sacubitril inhibits __________, the enzyme that normally degrades ________.

A

naprilysin; BNP

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14
Q

BNP and ANP work to __________.

A

lower blood pressure by inducing peeing and vasodilation

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15
Q

Digoxin’s half life is __________.

A

38 hours

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16
Q

Digoxin toxicity can arise from ______________.

A

hypokalemia, hypomagnesemia, and hypercalcemia

17
Q

Dopamine is _____________.

A

an endogenous precursor of norepinephrine