Inflammation and Atherosclerosis

Question 1

What receptors mediates monocyte adhesion?

Answer 1

CD11 and VLA-4

Question 2

_________ cells promote plaque instability and neovascularization.

Answer 2

Th17

Question 3

What processes make a plaque less stable?

Answer 3

Neovascularization, release of MMPs, and macrophage apoptosis leading to a necrotic core

Question 4

Vulnerable plaques have more _____________.

Answer 4

RBC fragments, iron, and disrupted vessels

Question 5

Statins lower both _________________.

Answer 5

LDL and CRP levels

Question 6

People with rheumatoid arthritis have (one study showed) a higher incidence of ____________.

Answer 6

vulnerable plaque formation on the LAD

Question 7

TNFalpha antagonists have been shown to ______________.

Answer 7

decrease the incidence of cardiovascular events

Question 8

Prednisone actually increases ____________.

Answer 8

cardiovascular events

Question 9

Blockade of _________ may reduce atherosclerosis.

Answer 9

IL-17A

Question 10

In addition to being produced by hepatocytes, C-reactive protein might also be produced by ____________.

Answer 10

smooth muscle cells and macrophages

Question 11

What did the JUPITER trial show?

Answer 11

It showed that those with low LDLs and high CRPs had a slight reduction in MIs and mortality from taking a statin.

Question 12

In patients with chronic inflammation, HDL ____________.

Answer 12

loses its anti-atherogenic ability

Question 13

Those with rheumatoid arthritis have a similar prevalence of CAD, but they have more __________.

Answer 13

ruptured plaques

Question 14

Those with severe _________ have a higher risk of death from CV events.

Answer 14

psoriasis