Pathophysiology of Water Handling Flashcards
Osmoregulation is achieved by ____________.
water excretion and intake
What two things can stimulate the release of ADH?
The baroreceptors of the aortic arch and carortid sinus
Osmoreceptors
ADH increases exponentially if the blood volume decreases by _________, even despite decreases in osmolarity.
6% - 8%
Severe volume depletion can cause ___________.
hyponatremia, because volume depletion induces ADH release and subsequent water resorption
Hypo- and hypernatremia refer to states of ______________.
sodium concentration, not total sodium content
Hypertonic hyponatremia is most often caused by ____________.
uncontrolled diabetes
Isotonic hyponatremia can result from _____________.
lab artifact, hyperlipidemia, or hyperproteinemia
Other than hemorrhage, what can cause hypovolemic hyponatremia?
GI losses
Renal loss (excessive diuretic use or mineralocorticoid deficiency)
Excessive sweating
How is hypovolemic hyponatremia treated?
Give normal saline to restore blood volume
Why is ADH released in those with liver cirrhosis?
The splanchnic vasculature is excessively dilated, which is sensed by the body as decreased effective blood volume. This stimulates ADH release.
How is hypervolemic hyponatremia treated?
Water and salt restriction Loop diuretics (stop thiazides) Inotropes for CHF
What usually causes euvolemic hyponatremia?
Excessive ADH release
SIADH is characterized by ____________.
euvolemic hyponatremia and urine that is not maximally dilute (that is, greater than 50 to 100 mOsm/kg)
What causes SIADH?
Carcinomas (duodenum, pancreas, and small cell carcinoma)
CNS disorders
Pulmonary diseases
How can euvolemic hyponatremia be treated?
Hypertonic saline for seizures
Water restriction
Removal of causative drugs
ADH antagonists